Invention Grant
- Patent Title: Isolated phosphotriesterase polypeptides, polynucleotides encoding same and uses thereof in treating or preventing organophosphate exposure associated damage
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Application No.: US15535050Application Date: 2015-12-10
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Publication No.: US10688330B2Publication Date: 2020-06-23
- Inventor: Dan S. Tawfik , Haim Leader , Yaacov Ashani , Izhack Cherny , Moshe Goldsmith , Per Jr. Greisen , Sagar D. Khare , Gustav Oberdorfer , David Baker , Sarel Fleishman , Adi Goldenzweig , Nidhi Aggarwal
- Applicant: Yeda Research and Development Co. Ltd. , University of Washington
- Applicant Address: IL Rehovot US WA Seattle
- Assignee: Yeda Research and Development Co. Ltd.,University of Washington
- Current Assignee: Yeda Research and Development Co. Ltd.,University of Washington
- Current Assignee Address: IL Rehovot US WA Seattle
- International Application: PCT/IL2015/051203 WO 20151210
- International Announcement: WO2016/092555 WO 20160616
- Main IPC: C12N9/16
- IPC: C12N9/16 ; A61P25/00 ; A62D3/02 ; A62D101/02 ; A62D101/26
Abstract:
A genetically modified polypeptide is disclosed which comprises an amino acid sequence of phosphotriesterase (PTE) having at least twice the catalytic efficiency for a V-type nerve agent as a polypeptide which consists of the sequence as set forth in SEQ ID NO: 1, when assayed under identical conditions.
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