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公开(公告)号:US10688330B2
公开(公告)日:2020-06-23
申请号:US15535050
申请日:2015-12-10
Inventor: Dan S. Tawfik , Haim Leader , Yaacov Ashani , Izhack Cherny , Moshe Goldsmith , Per Jr. Greisen , Sagar D. Khare , Gustav Oberdorfer , David Baker , Sarel Fleishman , Adi Goldenzweig , Nidhi Aggarwal
IPC: C12N9/16 , A61P25/00 , A62D3/02 , A62D101/02 , A62D101/26
Abstract: A genetically modified polypeptide is disclosed which comprises an amino acid sequence of phosphotriesterase (PTE) having at least twice the catalytic efficiency for a V-type nerve agent as a polypeptide which consists of the sequence as set forth in SEQ ID NO: 1, when assayed under identical conditions.