公开(公告)号：US10688330B2

公开(公告)日：2020-06-23

申请号：US15535050

申请日：2015-12-10

Applicant: Yeda Research and Development Co. Ltd. ,  University of Washington

Inventor： Dan S. Tawfik ,  Haim Leader ,  Yaacov Ashani ,  Izhack Cherny ,  Moshe Goldsmith ,  Per Jr. Greisen ,  Sagar D. Khare ,  Gustav Oberdorfer ,  David Baker ,  Sarel Fleishman ,  Adi Goldenzweig ,  Nidhi Aggarwal

IPC: C12N9/16 ,  A61P25/00 ,  A62D3/02 ,  A62D101/02 ,  A62D101/26

Abstract: A genetically modified polypeptide is disclosed which comprises an amino acid sequence of phosphotriesterase (PTE) having at least twice the catalytic efficiency for a V-type nerve agent as a polypeptide which consists of the sequence as set forth in SEQ ID NO: 1, when assayed under identical conditions.

公开(公告)号：US20190083836A1

公开(公告)日：2019-03-21

申请号：US15535050

申请日：2015-12-10

Applicant: Yeda Research and Development Co, Ltd ,  University of Washington

Inventor： Dan S. TAWFIK ,  Haim LEADER ,  Yaacov ASHANI ,  Izhack CHERNY ,  Moshe GOLDSMITH ,  Per Jr. GRIESEN ,  Sagar D KHARE ,  Gustav Oberdorfer ,  David Baker ,  Sarel Fleishman ,  Adi Goldenzweig ,  Nidhi Aggarwal

IPC: A62D3/02 ,  C12N9/16 ,  A61P25/00

CPC classification number: A62D3/02 ,  A61P25/00 ,  A62D2101/02 ,  A62D2101/26 ,  C12N9/16 ,  C12Y301/08001

Abstract: A genetically modified polypeptide is disclosed which comprises an amino acid sequence of phosphotriesterase (PTE) having at least twice the catalytic efficiency for a V-type nerve agent as a polypeptide which consists of the sequence as set forth in SEQ ID NO: 1, when assayed under identical conditions.

公开(公告)号：US20250049731A1

公开(公告)日：2025-02-13

申请号：US18912238

申请日：2024-10-10

Applicant: University of Washington

Inventor： Robert Divine ,  Ivan Vulovic ,  David Baker ,  William H. Sheffler ,  Franziska Seeger

IPC: A61K9/51 ,  C07K14/32 ,  C07K16/28

Abstract: Polypeptides are disclosed comprising an (Fc) binding domain, a helical polypeptide monomer, and an oligomer domain, polymers thereof, and uses thereof.

公开(公告)号：US20250011437A1

公开(公告)日：2025-01-09

申请号：US18627108

申请日：2024-04-04

Applicant: The Board of Trustees of the Leland Stanford Junior University ,  University of Washington

Inventor： Kenan Christopher Garcia ,  David Baker ,  Claudia Yvonne Janda ,  Luke Dang ,  James Daniel Moody

IPC: C07K16/28 ,  C07K16/30

Abstract: Wnt signaling agonist compositions and methods for their use are provided. Wnt signaling agonists of the invention comprise a frizzled binding moiety, which is fused or conjugated to an LRP5 or LRP6 binding moiety.

公开(公告)号：US20230357323A1

公开(公告)日：2023-11-09

申请号：US18003572

申请日：2021-06-25

Applicant: University of Washington

Inventor： Stephanie Berger ,  Franziska Seeger ,  David Baker ,  Ta-Yi Yu

IPC: C07K14/00 ,  C12N15/63 ,  A61P29/00

CPC classification number: C07K14/001 ,  C12N15/63 ,  A61P29/00

Abstract: The present disclosure provides human 1L-23R (WL-23R) binding polypeptides, conditionally maximally active SilL˜23R binding proteins, multimers thereof, and methods for using the polypeptides and binding proteins for therapeutic use.

公开(公告)号：US20230279055A1

公开(公告)日：2023-09-07

申请号：US18177367

申请日：2023-03-02

Applicant: UNIVERSITY OF WASHINGTON ,  El Consejo Superior de Investigaciones Científicas

Inventor： David Baker ,  Tamuka Chidyausiku ,  Jason C. Klima ,  Enrique Marcos Benteo ,  F. Xavier Gomis Rüth ,  Soraia Dos Reis Mendes ,  Ulrich Eckhard ,  Marta Nadal Rovira ,  Jorge Luis Roel Touris

IPC: C07K14/00 ,  C12N15/63

CPC classification number: C07K14/00 ,  C12N15/63

Abstract: The disclosure provides antibody-like polypeptides of the formula X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12-X13-X14-X15, wherein the domains are as defined herein, nucleic acids encoding the polypeptides, and methods for use and design of the polypeptides.

公开(公告)号：US20230159595A1

公开(公告)日：2023-05-25

申请号：US17934343

申请日：2022-09-22

Applicant: University of Washington

Inventor： David Baker ,  Jacob B. BALE ,  Neil P. KING ,  William H. SHEFFLER ,  Daniel ELLIS

IPC: C07K14/00

CPC classification number: C07K14/00

Abstract: Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using such synthetic nanostructures are disclosed herein.

公开(公告)号：US20220354893A1

公开(公告)日：2022-11-10

申请号：US17815092

申请日：2022-07-26

Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD UNIVERSITY ,  UNIVERSITY OF WASHINGTON

Inventor： Kenan Christopher Garcia ,  Jonathan Sockolosky ,  David Baker ,  Chris King

IPC: A61K35/17 ,  A61K38/17 ,  A61K38/20 ,  C07K14/55 ,  C12N5/0783 ,  C12N15/10

Abstract: Engineered orthogonal cytokine receptor/ligand pairs, and methods of use thereof, are provided.

公开(公告)号：US20220235110A1

公开(公告)日：2022-07-28

申请号：US17698553

申请日：2022-03-18

Applicant: UNIVERSITY OF WASHINGTON ,  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

Inventor： Daniel Adriano Silva Manzano ,  Shawn Yu ,  Umut Ulge ,  David Baker ,  Kenan Christopher Garcia ,  Jamie Spangler ,  Carl WALKEY

IPC: C07K14/55 ,  C07K14/54 ,  A61K47/62 ,  A61K47/60

Abstract: De novo designed polypeptides that bind to IL-2 receptor βc heterodimer (IL-2Rβc), IL-4 receptor αc heterodimer (IL-4Rαc), or IL-13 receptor α subunit (IL-13Rα) are disclosed, as are methods for using and designing the polypeptides.

公开(公告)号：US11117944B2

公开(公告)日：2021-09-14

申请号：US16905669

申请日：2020-06-18

Applicant: UNIVERSITY OF WASHINGTON ,  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

Inventor： Daniel Adriano Silva Manzano ,  Shawn Yu ,  Umut Ulge ,  David Baker ,  Kenan Christopher Garcia ,  Jamie Spangler ,  Carl Walkey ,  Alfredo Quijano Rubio ,  Brian Weitzner

IPC: C07K14/55 ,  C07K14/54 ,  A61K47/62 ,  A61K47/60 ,  A61K38/00

Abstract: De novo designed polypeptides that bind to IL-2 receptor βγc heterodimer (IL-2Rβγc), IL-4 receptor αγc heterodimer (IL-4Rαγc), or IL-13 receptor α subunit (IL-13Rα) are disclosed, as are methods for using and designing the polypeptides.