Invention Grant
- Patent Title: Cystine knot scaffold platform
-
Application No.: US15944700Application Date: 2018-04-03
-
Publication No.: US10696721B2Publication Date: 2020-06-30
- Inventor: Rami Hannoush , Harini Kaluarachchi , Aaron Nile , Cameron Noland , Yingnan Zhang , Lijuan Zhou , Xinxin Gao
- Applicant: Genentech, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Morrison & Foerster LLP
- Main IPC: A61K9/50
- IPC: A61K9/50 ; C07K14/00 ; C07K14/415 ; C07K14/81 ; A61K38/00 ; A61K47/34 ; A61K38/16 ; C07K14/47 ; A61K9/00
Abstract:
Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.
Public/Granted literature
- US20180291069A1 CYSTINE KNOT SCAFFOLD PLATFORM Public/Granted day:2018-10-11
Information query
