公开(公告)号：US10428125B2

公开(公告)日：2019-10-01

申请号：US15267087

申请日：2016-09-15

Applicant: Genentech, Inc.

Inventor： Rami Hannoush ,  Harini Kaluarachchi ,  Aaron Nile ,  Cameron Noland ,  Yingnan Zhang ,  Lijuan Zhou ,  Xinxin Gao

IPC: C07K14/415 ,  C07K14/00 ,  A61K38/16 ,  A61K9/00 ,  A61K47/34 ,  A61K38/00 ,  C07K14/81 ,  C07K14/47 ,  A61K9/50

Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.

公开(公告)号：US10696721B2

公开(公告)日：2020-06-30

申请号：US15944700

申请日：2018-04-03

Applicant: Genentech, Inc.

Inventor： Rami Hannoush ,  Harini Kaluarachchi ,  Aaron Nile ,  Cameron Noland ,  Yingnan Zhang ,  Lijuan Zhou ,  Xinxin Gao

IPC: A61K9/50 ,  C07K14/00 ,  C07K14/415 ,  C07K14/81 ,  A61K38/00 ,  A61K47/34 ,  A61K38/16 ,  C07K14/47 ,  A61K9/00

Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.

公开(公告)号：US11155586B2

公开(公告)日：2021-10-26

申请号：US16574917

申请日：2019-09-18

Applicant: Genentech, Inc.

Inventor： Rami Hannoush ,  Harini Kaluarachchi ,  Aaron Nile ,  Cameron Noland ,  Yingnan Zhang ,  Lijuan Zhou ,  Xinxin Gao

IPC: C07K14/415 ,  C07K14/00 ,  A61K47/34 ,  A61K38/16 ,  A61K9/00 ,  A61K9/50 ,  C07K14/47 ,  C07K14/81 ,  A61K38/00

Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.

公开(公告)号：US11407794B2

公开(公告)日：2022-08-09

申请号：US16544394

申请日：2019-08-19

Applicant: Genentech, Inc.

Inventor： Rami Hannoush ,  Harini Kaluarachchi ,  Aaron Nile ,  Cameron Noland ,  Yingnan Zhang ,  Lijuan Zhou ,  Xinxin Gao

IPC: C07K14/415 ,  C07K14/00 ,  A61K47/34 ,  A61K38/16 ,  A61K9/00 ,  A61K9/50 ,  C07K14/47 ,  C07K14/81 ,  A61K38/00

Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.

公开(公告)号：US11078243B2

公开(公告)日：2021-08-03

申请号：US16574910

申请日：2019-09-18

Applicant: Genentech, Inc.

Inventor： Rami Hannoush ,  Harini Kaluarachchi ,  Aaron Nile ,  Cameron Noland ,  Yingnan Zhang ,  Lijuan Zhou ,  Xinxin Gao

IPC: C07K14/415 ,  C07K14/00 ,  A61K47/34 ,  A61K38/16 ,  A61K9/00 ,  A61K9/50 ,  C07K14/47 ,  C07K14/81 ,  A61K38/00

Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.