- 专利标题： Modular, multifunctional nanoparticle-based bioconjugate for realtime visualization of cellular membrane potential
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申请号： US15882259申请日： 2018-01-29
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公开(公告)号： US10705092B2公开(公告)日： 2020-07-07
- 发明人: James B. Delehanty , Michael H. Stewart , Okhil Nag , Jeffrey R. Deschamps , Kimihiro Susumu , Eunkeu Oh , Lauren D. Field , Alexander L. Efros , Alan L. Huston , Igor L. Medintz , Philip E. Dawson
- 申请人： The Government of the United States of America, as represented by the Secretary of the Navy
- 申请人地址： US DC Washington
- 专利权人： The Government of the United States of Americam as Represented by the Secretary of the Navy
- 当前专利权人： The Government of the United States of Americam as Represented by the Secretary of the Navy
- 当前专利权人地址： US DC Washington
- 代理机构： US Naval Research Laboratory
- 代理商 Roy Roberts
- 主分类号： G01N33/58
- IPC分类号： G01N33/58
摘要：
A construct for detecting cellular membrane potential includes a nanoparticle operable as an electron donor; a modular peptide attached to the nanoparticle, the peptide comprising a nanoparticle association domain, a motif configured to mediate peptide insertion into the plasma membrane, and at least one attachment point for an electron acceptor positioned at a controlled distance from the nanoparticle; and an electron acceptor. The nanoparticle can be a quantum dot and the electron acceptor can be C60 fullerene. Emission correlates with cellular membrane potential.
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