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1.发明申请公开(公告)号：US20190201547A1
公开(公告)日：2019-07-04
申请号：US16236899
申请日：2018-12-31
发明人： James B. Delehanty , Lauren D. Field , Igor L. Medintz , Scott Walper , Kimihiro Susumu , Guillermo Lasarte-Aragones
IPC分类号： A61K47/69 , A61K31/704 , A61K49/00 , A61K47/65
CPC分类号： A61K47/6951 , A61K31/704 , A61K47/65 , A61K47/6929 , A61K49/0093
摘要： A new nanoparticle (NP)-based, multicomponent delivery/reporter construct can mediate the controlled, spatiotemporal, active release of an appended cargo to the cytosol of mammalian cells. The construct comprises components including (1) a central NP scaffold, for example a photoluminescent quantum dot (QD); (2) a bridging structure that self-assembles to the NP surface (for example, histidine-tagged maltose binding protein); and (3) a cargo, for example a ligand-dye/drug conjugate, incorporating a ligand that allows the cargo to releasably bind to the bridging structure (e.g., a β-cyclodextrin ligand for binding to maltose binding protein).
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公开(公告)号：US10705092B2
公开(公告)日：2020-07-07
申请号：US15882259
申请日：2018-01-29
发明人： James B. Delehanty , Michael H. Stewart , Okhil Nag , Jeffrey R. Deschamps , Kimihiro Susumu , Eunkeu Oh , Lauren D. Field , Alexander L. Efros , Alan L. Huston , Igor L. Medintz , Philip E. Dawson
IPC分类号： G01N33/58
摘要： A construct for detecting cellular membrane potential includes a nanoparticle operable as an electron donor; a modular peptide attached to the nanoparticle, the peptide comprising a nanoparticle association domain, a motif configured to mediate peptide insertion into the plasma membrane, and at least one attachment point for an electron acceptor positioned at a controlled distance from the nanoparticle; and an electron acceptor. The nanoparticle can be a quantum dot and the electron acceptor can be C60 fullerene. Emission correlates with cellular membrane potential.
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3.发明申请公开(公告)号：US20180326097A1
公开(公告)日：2018-11-15
申请号：US16031094
申请日：2018-07-10
发明人： James B. Delehanty , Michael H. Stewart , Okhil Nag , Jeffrey R. Deschamps , Kimihiro Susumu , Eunkeu Oh , Lauren D. Field , Alexander L. Efros , Alan L. Huston , Igor L. Medintz , Philip E. Dawson , Nashaat Rasheed , Parag V. Chitnis , John R. Cressman
CPC分类号： A61K49/222 , A61K49/221 , G01N33/542 , G01N33/588
摘要： A construct for detecting cellular membrane potential includes a nanoparticle operable as an electron donor; a modular peptide attached to the nanoparticle, the peptide comprising a nanoparticle association domain, a motif configured to mediate peptide insertion into the plasma membrane, and at least one attachment point for an electron acceptor positioned at a controlled distance from the nanoparticle; and an electron acceptor. The nanoparticle can be a quantum dot and the electron acceptor can be C60 fullerene. Photoacoustic emission from the construct correlates with cellular membrane potential.
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公开(公告)号：US11287430B2
公开(公告)日：2022-03-29
申请号：US16894920
申请日：2020-06-08
发明人： James B. Delehanty , Michael H. Stewart , Okhil Nag , Jeffrey R. Deschamps , Kimihiro Susumu , Eunkeu Oh , Lauren D. Field , Alexander L. Efros , Alan L. Huston , Igor L. Medintz , Philip E. Dawson
IPC分类号： G01N33/58
摘要： A construct for detecting cellular membrane potential includes a nanoparticle operable as an electron donor; a modular peptide attached to the nanoparticle, the peptide comprising a nanoparticle association domain, a motif configured to mediate peptide insertion into the plasma membrane, and at least one attachment point for an electron acceptor positioned at a controlled distance from the nanoparticle; and an electron acceptor. The nanoparticle can be a quantum dot and the electron acceptor can be C60 fullerene. Emission correlates with cellular membrane potential.
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公开(公告)号：US10780185B2
公开(公告)日：2020-09-22
申请号：US16031094
申请日：2018-07-10
发明人： James B. Delehanty , Michael H. Stewart , Okhil Nag , Jeffrey R. Deschamps , Kimihiro Susumu , Eunkeu Oh , Lauren D. Field , Alexander L. Efros , Alan L. Huston , Igor L. Medintz , Philip E. Dawson , Nashaat Rasheed , Parag V. Chitnis , John R. Cressman
IPC分类号： A61K49/22 , G01N33/58 , G01N33/542
摘要： A construct for detecting cellular membrane potential includes a nanoparticle operable as an electron donor; a modular peptide attached to the nanoparticle, the peptide comprising a nanoparticle association domain, a motif configured to mediate peptide insertion into the plasma membrane, and at least one attachment point for an electron acceptor positioned at a controlled distance from the nanoparticle; and an electron acceptor. The nanoparticle can be a quantum dot and the electron acceptor can be C60 fullerene. Photoacoustic emission from the construct correlates with cellular membrane potential.
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6.发明申请公开(公告)号：US20180217153A1
公开(公告)日：2018-08-02
申请号：US15882259
申请日：2018-01-29
发明人： James B. Delehanty , Michael H. Stewart , Okhil Nag , Jeffrey R. Deschamps , Kimihiro Susumu , Eunkeu Oh , Lauren D. Field , Alexander L. Efros , Alan L. Huston , Igor L. Medintz , Philip E. Dawson
IPC分类号： G01N33/58
摘要： A construct for detecting cellular membrane potential includes a nanoparticle operable as an electron donor; a modular peptide attached to the nanoparticle, the peptide comprising a nanoparticle association domain, a motif configured to mediate peptide insertion into the plasma membrane, and at least one attachment point for an electron acceptor positioned at a controlled distance from the nanoparticle; and an electron acceptor. The nanoparticle can be a quantum dot and the electron acceptor can be C60 fullerene. Emission correlates with cellular membrane potential.
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