Invention Grant
- Patent Title: Crystal structure of the large ribosomal subunit from S. aureus
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Application No.: US16726290Application Date: 2019-12-24
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Publication No.: US10723770B2Publication Date: 2020-07-28
- Inventor: Ada Yonath , Zohar Eyal , Donna Matzov , Haim Rozenberg , Ella Zimmerman , Anat Bashan
- Applicant: Yeda Research and Development Co. Ltd.
- Applicant Address: IL Rehovot
- Assignee: Yeda Research and Development Co. Ltd.
- Current Assignee: Yeda Research and Development Co. Ltd.
- Current Assignee Address: IL Rehovot
- Main IPC: C07K14/31
- IPC: C07K14/31 ; C07H17/08 ; C07D263/20 ; C07D211/54 ; G16B15/00 ; G16B30/00 ; G16C20/50 ; G16B35/00 ; G16C20/60
Abstract:
A composition-of-matter comprising a crystallized form of a large ribosomal (50S) subunit of a pathogenic bacterium, and the atomic coordinates of the three-dimensional structure thereof are provided herein, as well as methods for crystallizing the same, and using the atomic coordinates of the same to design de novo ligands with high specificity thereto.
Public/Granted literature
- US20200131232A1 CRYSTAL STRUCTURE OF THE LARGE RIBOSOMAL SUBUNIT FROM S. AUREUS Public/Granted day:2020-04-30
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