公开(公告)号：US10556934B2

公开(公告)日：2020-02-11

申请号：US15547499

申请日：2016-01-26

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Ada Yonath ,  Zohar Eyal ,  Donna Matzov ,  Haim Rozenberg ,  Ella Zimmerman ,  Anat Bashan

IPC: C07K14/31 ,  G16B15/00 ,  G16C20/50 ,  C07D211/54 ,  C07D263/20 ,  C07H17/08

Abstract: A composition-of-matter comprising a crystallized form of a large ribosomal (50S) subunit of a pathogenic bacterium, and the atomic coordinates of the three-dimensional structure thereof are provided herein, as well as methods for crystallizing the same, and using the atomic coordinates of the same to design de novo ligands with high specificity thereto.

公开(公告)号：US10723770B2

公开(公告)日：2020-07-28

申请号：US16726290

申请日：2019-12-24

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Ada Yonath ,  Zohar Eyal ,  Donna Matzov ,  Haim Rozenberg ,  Ella Zimmerman ,  Anat Bashan

IPC: C07K14/31 ,  C07H17/08 ,  C07D263/20 ,  C07D211/54 ,  G16B15/00 ,  G16B30/00 ,  G16C20/50 ,  G16B35/00 ,  G16C20/60

Abstract: A composition-of-matter comprising a crystallized form of a large ribosomal (50S) subunit of a pathogenic bacterium, and the atomic coordinates of the three-dimensional structure thereof are provided herein, as well as methods for crystallizing the same, and using the atomic coordinates of the same to design de novo ligands with high specificity thereto.