- 专利标题： Compounds, compositions, and methods for increasing CFTR activity
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申请号： US16190964申请日： 2018-11-14
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公开(公告)号： US10738040B2公开(公告)日： 2020-08-11
- 发明人: Cecilia M. Bastos , Benito Munoz , Bradley Tait
- 申请人： Proteostasis Therapeutics, Inc.
- 申请人地址： US MA Boston
- 专利权人： Proteostasis Therapeutics, Inc.
- 当前专利权人： Proteostasis Therapeutics, Inc.
- 当前专利权人地址： US MA Boston
- 代理机构： Goodwin Procter LLP
- 主分类号： C07D261/08
- IPC分类号： C07D261/08 ; C07D413/12 ; C07F7/18 ; C07D413/14 ; C07D231/12 ; C07D233/61 ; C07D417/12 ; C07D261/18 ; C07D285/12 ; A61K31/16 ; A61K31/42 ; A61K31/422 ; A61K31/4245 ; A61K31/433 ; A61K31/695 ; A61K45/06 ; C07C243/36
摘要：
The present disclosure features disclosed compounds which can increase cystic fibrosis transmembrane conductance regulator (CFTR) activity as measured in human bronchial epithelial (hBE) cells. The present disclosure also features methods of treating a condition associated with decreased CFTR activity or a condition associated with a dysfunction of proteostasis comprising administering to a subject an effective amount of a disclosed compound.
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