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公开(公告)号：US20210061823A1
公开(公告)日：2021-03-04
申请号：US16848345
申请日：2020-04-14
发明人： Benito Munoz , Daniel Parks , Cecilia M. Bastos
IPC分类号： C07F7/08 , C07D215/56 , A61K31/695 , A61K45/06
摘要： The present disclosure is directed to disclosed compounds that modulate e.g., address underlying defects in cellular processing of CFTR activity.
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公开(公告)号：US20200308198A1
公开(公告)日：2020-10-01
申请号：US16902019
申请日：2020-06-15
发明人： Matthew Cullen , Sheila Hauck , Bolin Geng , Megan Foley , Cecilia M. Bastos , Benito Munoz , Markus Haeberlein , Bradley Tait
IPC分类号： C07F7/18 , C07D401/14 , C07D401/06 , C07D403/06 , C07D471/04 , C07D209/12 , C07B59/00 , C07D209/14 , C07D417/14 , C07D519/00
摘要： The present invention is directed to compounds having the Formula (I), (II), (III), (IV), and (V), compositions thereof, and methods for the treatment of a condition associated with a dysfunction in proteostasis.
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公开(公告)号：US10738011B2
公开(公告)日：2020-08-11
申请号：US15539401
申请日：2015-12-23
发明人： Cecilia M. Bastos , Benito Munoz , Bradley Tait
IPC分类号： C07D231/14 , C07D249/06 , C07D413/12 , C07D403/12 , C07D405/12 , A61P11/00 , A61K31/415 , A61K31/4155 , A61K31/4178 , A61K31/5377 , A61K45/06 , G01N33/68
摘要： The present disclosure is based, in part, on the discovery that disclosed compounds such as those having Formula (IVa), (Va), (IV), or (V) can increase cystic fibrosis transmembrane conductance regulator (CFTR) activity as measured in human bronchial epithelial (hBE) cells.
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公开(公告)号：US10548878B2
公开(公告)日：2020-02-04
申请号：US15747290
申请日：2016-07-25
发明人： Benito Munoz , Cecilia M. Bastos , John Miller
IPC分类号： A61K31/42 , A61K31/341 , A61K31/422 , A61K31/433 , A61K31/454 , A61K31/47 , A61K45/06 , A61P11/12 , A61K31/4178 , A61K31/4245 , A61K31/5377
摘要： The present disclosure features compounds such as those having the Formulae (I) and (II), which can increase cystic fibrosis transmembrane conductance regulator (CFTR) activity as measured in human bronchial epithelial (hBE) cells. The present disclosure also features methods of treating a condition associated with decreased CFTR activity or a condition associated with a dysfunction of proteostasis comprising administering to a subject an effective amount of a disclosed compound, such as a compound of Formula (I) or (II).
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公开(公告)号：US10392372B2
公开(公告)日：2019-08-27
申请号：US15539392
申请日：2015-12-23
发明人： Cecilia M. Bastos , Benito Munoz , Bradley Tait
IPC分类号： A61K31/42 , A61K45/06 , G01N33/50 , A61K31/422 , A61K31/433 , C07D261/18 , C07D307/54 , C07D307/68 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , A61K31/4245 , A61K31/5377
摘要： The present disclosure is directed to disclosed compounds that increase cystic fibrosis transmembrane conductance regulator (CFTR) activity as measured in human bronchial epithelial (hBE) cells.
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公开(公告)号：US20180282352A1
公开(公告)日：2018-10-04
申请号：US15830261
申请日：2017-12-04
发明人： Matthew Cullen , Sheila Hauck , Bolin Geng , Megan Foley , Cecilia M. Bastos , Benito Munoz , Markus Haeberlein
IPC分类号： C07F7/18 , C07D209/14 , C07D417/14 , C07D519/00 , C07B59/00 , C07D401/14 , C07D209/12 , C07D471/04 , C07D403/06 , C07D401/06
摘要： The present invention is directed to compounds having the Formula (I), (II), (III), (IV), and (V), compositions thereof, and methods for the treatment of a condition associated with a dysfunction in proteostasis.
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公开(公告)号：US20170369480A1
公开(公告)日：2017-12-28
申请号：US15539392
申请日：2015-12-23
发明人： Cecilia M. Bastos , Benito Munoz , Bradley Tait
IPC分类号： C07D413/12 , C07D417/12 , C07D413/14 , C07D409/14 , C07D307/68 , C07D261/18 , A61K45/06 , A61K31/5377 , A61K31/433 , A61K31/4245 , A61K31/422 , G01N33/50 , A61K31/42
CPC分类号： C07D413/12 , A61K31/42 , A61K31/422 , A61K31/4245 , A61K31/433 , A61K31/5377 , A61K45/06 , C07D261/18 , C07D307/54 , C07D307/68 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/14 , C07D417/12 , G01N33/502 , G01N33/5044
摘要： The present disclosure is directed to disclosed compounds that increase cystic fibrosis transmembrane conductance regulator (CFTR) activity as measured in human bronchial epithelial (hBE) cells.
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公开(公告)号：US20220175735A1
公开(公告)日：2022-06-09
申请号：US17354751
申请日：2021-06-22
发明人： John Miller , Cecilia M. Bastos , Benito Munoz
IPC分类号： A61K31/422 , A61K31/404 , A61K31/4245 , A61K31/47 , A61K31/7036 , A61K45/06 , A61K31/443 , A61P11/06 , A61P11/08 , A61K9/00 , A61K31/341 , A61K31/4192 , A61K31/433 , A61K31/454 , A61K31/5377
摘要： The present disclosure features disclosed method of treating disorders such as COPD, bronchitis and/or asthma using disclosed compounds, optionally together with one or more additional active agents. Contemplated methods include administrating orally or by inhalation to a patient one or more disclosed compounds.
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公开(公告)号：US11136313B2
公开(公告)日：2021-10-05
申请号：US16716765
申请日：2019-12-17
发明人： Benito Munoz , Cecilia M. Bastos , Daniel Parks , David Kombo
IPC分类号： C07D405/14 , C07D405/04 , C07D413/14 , C07D401/04 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04 , C07D471/04 , C07D487/04 , C07D493/08 , A61K45/06 , A61P11/00
摘要： The present disclosure is directed to disclosed compounds that modulate, e.g., address underlying defects in cellular processing of CFTR activity.
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公开(公告)号：US11098035B2
公开(公告)日：2021-08-24
申请号：US16510406
申请日：2019-07-12
发明人： Cecilia M. Bastos , Benito Munoz , Bradley Tait
IPC分类号： C07D413/12 , A61K31/42 , A61K31/4245 , C07D413/14 , C07D409/14 , C07D417/12 , C07D261/18 , C07D307/54 , C07D405/12 , C07D407/12 , A61K31/422 , A61K31/433 , A61K31/5377 , A61K45/06 , C07D307/68 , G01N33/50
摘要： The present disclosure is directed to disclosed compounds that increase cystic fibrosis transmembrane conductance regulator (CFTR) activity as measured in human bronchial epithelial (hBE) cells.
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