Invention Grant
- Patent Title: High-throughput screening of functional antibody fragments, immunoconjugate comprising the same, and adaptor-drug conjugate for screening
-
Application No.: US15619835Application Date: 2017-06-12
-
Publication No.: US10752673B2Publication Date: 2020-08-25
- Inventor: An-Suei Yang , Hong-Sen Chen , Chung-Ming Yu , Shin-Chen Hou , Wei-Ying Kuo , Yi-Kai Chiu , Yueh-Liang Tsou , Hung-Ju Hsu , Hwei-Jiung Wang , Shih-Hsien Chuang , Chao-Pin Lee
- Applicant: Academia Sinica
- Applicant Address: TW Taipei
- Assignee: ACADEMIA SINICA
- Current Assignee: ACADEMIA SINICA
- Current Assignee Address: TW Taipei
- Main IPC: A61K39/395
- IPC: A61K39/395 ; A61K39/00 ; A61K39/02 ; C07K16/00 ; A61K47/68 ; A61P35/00 ; C07K16/32 ; C07K19/00

Abstract:
Disclosed herein are methods for high-throughput screening of a functional antibody fragment for an immunoconjugate that targets a protein antigen. The method combines a phage-displayed synthetic antibody library and high-throughput cytotoxicity screening of non-covalently assembled immunotoxins or cytotoxic drug to identify highly functional synthetic antibody fragments for delivering toxin payloads.
Public/Granted literature
Information query