公开(公告)号：US20250082744A1

公开(公告)日：2025-03-13

申请号：US18927447

申请日：2024-10-25

Applicant: ACADEMIA SINICA

Inventor： Chi-Huey WONG ,  Hsin-Yu LIAO ,  Shih-Chi WANG ,  Yi-An KO ,  Kuo-I LIN ,  Che MA ,  Ting-Jen CHENG

IPC: A61K39/145 ,  A61K39/00 ,  A61P31/16 ,  C07K14/005

Abstract: The present disclosure relates to a chimeric influenza virus hemagglutinin (HA) polypeptide, comprising one or more stem domain sequence, each having at least 60% homology with a stem domain consensus sequence of H1 subtype HA (H1 HA) and/or H5 subtype HA (H5 HA), fused with one or more globular head domain sequence, each having at least 60% homology with a globular head domain consensus sequence of H1 subtype HA (H1 HA) or H5 subtype HA (H5 HA).

公开(公告)号：US12246021B2

公开(公告)日：2025-03-11

申请号：US17439630

申请日：2020-03-25

Applicant: Academia Sinica ,  National Health Research Institutes

Inventor： Weir-Torn Jiaang ,  Che-Kun James Shen

IPC: A61K31/52 ,  A61K31/5377 ,  A61P7/06 ,  C07D473/16 ,  C07D473/18

Abstract: Provided herein are compounds of Formula (I). The compounds described herein are useful in treating a disease associated with the expression of endogenous embryonic/fetal globin (e.g., γ globin) in erythrocytes (e.g., treating β-thalassemia and/or sickle cell disease through at least the induction of the globin gene expression in erythrocytes), and/or anemia (β-thalassemia and/or sickle cell anemia). The compounds described herein are useful in treating, delaying, and/or preventing the adverse effects of β-thalassemia and/or sickle cell disease, inducing γ globin production, and/or inducing the expression of embryonic/fetal globin genes in a subject, cell, tissue, or biological sample. Also provided in the present disclosure are pharmaceutical compositions, kits, and methods of using the compounds for inducing γ globin production described herein and for treating any of the target diseases described herein.

公开(公告)号：US20250028162A1

公开(公告)日：2025-01-23

申请号：US18909298

申请日：2024-10-08

Applicant: Academia Sinica

Inventor： Jung-Chi LIAO ,  Yi-De CHEN ,  Chih-Wei CHANG ,  Weng Man CHONG

IPC: G02B21/36 ,  G02B21/06 ,  G02B21/26 ,  G06V10/141 ,  G06V10/25 ,  G06V20/69 ,  H04N23/56 ,  H04N23/74

Abstract: A system and method for image-guided microscopic illumination are provided. A processing module controls an imaging assembly such that a camera acquires an image or images of a sample in multiple fields of view, and the image or images are automatically transmitted to a processing module and processed by the first processing module automatically in real-time based on a predefined criterion so as to determine coordinate information of an interested region in each field of view. The processing module also controls an illuminating assembly to illuminate the interested region of the sample according to the received coordinate information regarding to the interested region, with the illumination patterns changing among the fields of view.

公开(公告)号：US20250002866A1

公开(公告)日：2025-01-02

申请号：US18697799

申请日：2022-10-03

Applicant: ACADEMIA SINICA

Inventor： YING-CHIH CHANG

IPC: C12N5/09 ,  A61K45/06 ,  A61P35/00 ,  G01N33/50

Abstract: Methods of preparing cell cultures (e.g. tumor spheroids), methods of evaluating a therapeutic agent for cancer, and methods of cancer treatment.

公开(公告)号：US20240352477A1

公开(公告)日：2024-10-24

申请号：US18645166

申请日：2024-04-24

Applicant: ACADEMIA SINICA

Inventor： Su-May YU ,  Hsiang-Ting LEE ,  Tuan-Hua David HO

IPC: C12N15/82 ,  C12N9/12

CPC classification number: C12N15/8261 ,  C12N9/12 ,  C12N15/8227 ,  C12N15/8262 ,  C12N15/8273 ,  C12Y207/11001

Abstract: The present invention relates to a method for promoting growth of plants. Particularly, the method of the present invention features overexpression of a calcineurin B-like (CBL) interacting protein kinase15 (CIPK15) having an isoleucine (Ile) residue at position 48 (e.g. a CIPK15 from rice) in plants which can promote growth of the plants. The present invention also relates to a recombinant construct comprising a nucleic acid encoding the CIPK15 operably linked to a promoter. The present invention further relates to a transgenic plant overexpressing the CIPK15 exhibiting improved growth compared to a non-transgenic plant counterpart.

公开(公告)号：US20240316014A1

公开(公告)日：2024-09-26

申请号：US18126273

申请日：2023-03-24

Applicant: ACADEMIA SINICA ,  GWO XI STEM CELL APPLIED TECHNOLOGY CO., LTD.

Inventor： Joyce Jean LU ,  Hsiao-Chun Huang ,  Pei-Lun La ,  Chi-Hou Ng ,  Ming-Hsi Chuang

IPC: A61K31/44 ,  A61K9/00 ,  A61K31/352 ,  A61K31/404 ,  A61P25/00

CPC classification number: A61K31/44 ,  A61K9/0019 ,  A61K9/0085 ,  A61K31/352 ,  A61K31/404 ,  A61P25/00

Abstract: The present invention generally relates to a method for treating a demyelinating condition, in particular, by administering a combination comprising therapeutically effective amounts of a Rho-associated protein kinase (ROCK) inhibitor, a cyclin-dependent kinase (CDK) inhibitor, and a cyclic adenosine monophosphate (cAMP) activator to a subject in need thereof.

公开(公告)号：US12084479B2

公开(公告)日：2024-09-10

申请号：US16932372

申请日：2020-07-17

Applicant: Academia Sinica

Inventor： Chiaho Shih ,  Heng-Li Chen ,  Pei-Yi Su

IPC: C07K14/005 ,  A01N37/46 ,  A01N63/50 ,  A61K38/00 ,  A61P31/04 ,  C07K7/08

CPC classification number: C07K14/005 ,  A01N37/46 ,  A01N63/50 ,  A61P31/04 ,  C07K7/08 ,  A61K38/00 ,  C12N2730/10122 ,  C12N2730/10133

Abstract: An antimicrobial peptide, the peptide comprising 2 to 20 variable domains, each variable domain is a sequence of 2 to 20 consecutive basic amino acids, wherein (a) the variable domains are separated from each other by a variable linker, (b) the variable linker can have 1 to 20 any amino acids other than two or more consecutive basic amino acids, and (c) the peptide has no more than 100 amino acids.

公开(公告)号：US12059433B2

公开(公告)日：2024-08-13

申请号：US17077504

申请日：2020-10-22

Applicant: ACADEMIA SINICA

Inventor： Yi-Ping Hsueh ,  Tzyy-Nan Huang

IPC: A61K31/198 ,  A01K67/0276 ,  A01K67/0278 ,  A23K20/142 ,  A23K20/20 ,  A23L33/16 ,  A23L33/175 ,  A61K9/00 ,  A61K9/68 ,  A61K33/30 ,  A61K49/00 ,  A61P25/00 ,  G01N33/68

CPC classification number: A61K33/30 ,  A01K67/0276 ,  A01K67/0278 ,  A23K20/142 ,  A23K20/30 ,  A23L33/16 ,  A23L33/175 ,  A61K9/0056 ,  A61K9/0058 ,  A61K9/0095 ,  A61K31/198 ,  A61K49/0008 ,  A61P25/00 ,  G01N33/6806 ,  A01K2217/072 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0306 ,  A23V2002/00

Abstract: The present invention relates to a method for treating autism spectrum disorders (ASD) or ASD-like symptom, particularly by administering a zinc ion source and/or a serine component e.g. D-serine or its precursor/analogue, optionally in combination with a mixture of branched-chain amino acids (BCAAs). The present invention also relates to a combination, kit or composition for performing the method for treatment as described herein. Further described is use of a zinc ion source and/or a serine component and optional BCAAs for manufacturing a medicament for treating a symptom or disease characteristics associated with ASD or ASD-associated disorder or as a food supplement for ameliorating relevant symptoms in a subject in need thereof. The present invention further provides an animal model for autistic spectrum disorder (ASD) with deficient CTTNBP2 gene, and a method for identifying an ingredient effective in the treatment of ASD by using such animal model.

公开(公告)号：US20240219703A1

公开(公告)日：2024-07-04

申请号：US18608452

申请日：2024-03-18

Applicant: Academia Sinica

Inventor： Jung-Chi LIAO ,  Yi-De CHEN ,  Chih-Wei CHANG ,  Weng Man CHONG

IPC: G02B21/36 ,  G02B21/06 ,  G02B21/26 ,  G06V10/141 ,  G06V10/25 ,  G06V20/69 ,  H04N23/56 ,  H04N23/74

CPC classification number: G02B21/365 ,  G02B21/06 ,  G02B21/26 ,  G06V10/141 ,  G06V10/25 ,  G06V20/693 ,  H04N23/56 ,  H04N23/74

Abstract: A system and method for image-guided microscopic illumination are provided. A processing module controls an imaging assembly such that a camera acquires an image or images of a sample in multiple fields of view, and the image or images are automatically transmitted to a processing module and processed by the first processing module automatically in real-time based on a predefined criterion so as to determine coordinate information of an interested region in each field of view. The processing module also controls an illuminating assembly to illuminate the interested region of the sample according to the received coordinate information regarding to the interested region, with the illumination patterns changing among the fields of view.

公开(公告)号：US20240190866A1

公开(公告)日：2024-06-13

申请号：US18282219

申请日：2022-03-11

Applicant: Academia Sinica

Inventor： Wei-Chieh CHENG ,  Wei-An CHEN ,  Yu-Hsin CHEN ,  Ting-Jen CHENG ,  Chia-Ning SHEN ,  Chiao-Yun HSIEH ,  Pi-Fang HUNG

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

CPC classification number: C07D471/04 ,  A61K31/437 ,  A61P35/00

Abstract: Disclosed herein are novel polyhydroxylated indolizidine and pyrrolizidine derivates and methods for using the same in the treatment of cancer. The present polyhydroxylated indolizidine and pyrrolizidine derivates has the structure of formula (I),




wherein: X is O or b and c are independently an integral of 0 or and 1; R is selected from the group consisting of H, C1-6 alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, aralkyl, aralkenyl, aralkynyl, heteroaralkyl, heteroaralkenyl, beteroaralkynyl, heterocyclyl, alkoxy, aryloxy, and sulfonyl.