Invention Grant
- Patent Title: Enhanced thermal stability for adenoviral vectors through spray drying
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Application No.: US15757033Application Date: 2016-09-02
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Publication No.: US10752876B2Publication Date: 2020-08-25
- Inventor: Michael Thompson , Zhou Xing , Daniel Adam LeClair , Emily Cranston
- Applicant: MCMASTER UNIVERSITY
- Applicant Address: CA Hamilton
- Assignee: McMaster University
- Current Assignee: McMaster University
- Current Assignee Address: CA Hamilton
- Agency: Bereskin & Parr LLP/S.E.N.C.R.L., S.R.L.
- International Application: PCT/CA2016/051046 WO 20160902
- International Announcement: WO2017/035664 WO 20170309
- Main IPC: C07K16/24
- IPC: C07K16/24 ; A61K39/00 ; A61K39/395 ; C07K16/00 ; A61K38/17 ; C12N1/04 ; C12N15/86 ; C12N7/00 ; A61K9/00 ; A61K9/16 ; A61K39/235 ; A61K48/00
Abstract:
The present application includes stabilized adenovirus compositions comprising an adenovirus and an excipient, wherein the excipient comprises a mixture of dextran and mannitol in amounts effective to maintain at least 40% of the adenovirus activity after spray drying.
Public/Granted literature
- US20190062692A1 ENHANCED THERMAL STABILITY FOR ADENOVIRAL VECTORS THROUGH SPRAY DRYING Public/Granted day:2019-02-28
Information query
