公开(公告)号：US10752876B2

公开(公告)日：2020-08-25

申请号：US15757033

申请日：2016-09-02

Applicant: MCMASTER UNIVERSITY

Inventor： Michael Thompson ,  Zhou Xing ,  Daniel Adam LeClair ,  Emily Cranston

IPC: C07K16/24 ,  A61K39/00 ,  A61K39/395 ,  C07K16/00 ,  A61K38/17 ,  C12N1/04 ,  C12N15/86 ,  C12N7/00 ,  A61K9/00 ,  A61K9/16 ,  A61K39/235 ,  A61K48/00

Abstract: The present application includes stabilized adenovirus compositions comprising an adenovirus and an excipient, wherein the excipient comprises a mixture of dextran and mannitol in amounts effective to maintain at least 40% of the adenovirus activity after spray drying.

公开(公告)号：US20190062692A1

公开(公告)日：2019-02-28

申请号：US15757033

申请日：2016-09-02

Applicant: MCMASTER UNIVERSITY

Inventor： Michael Thompson ,  Zhou Xing ,  Daniel Adam LeClair ,  Emily Cranston

IPC: C12N1/04 ,  C12N15/86 ,  A61K9/00 ,  A61K39/235 ,  A61K9/16

CPC classification number: C12N1/04 ,  A61K9/0019 ,  A61K9/1623 ,  A61K9/1652 ,  A61K9/1682 ,  A61K39/235 ,  A61K48/00 ,  A61K2039/5256 ,  A61K2039/5258 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/10334 ,  C12N2710/10343 ,  C12N2710/10351

Abstract: The present application includes stabilized adenovirus compositions comprising an adenovirus and an excipient, wherein the excipient comprises a mixture of dextran and mannitol in amounts effective to maintain at least 40% of the adenovirus activity after spray drying.