- 专利标题: Antibody variants and uses thereof
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申请号: US14130543申请日: 2012-07-06
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公开(公告)号: US10759867B2公开(公告)日: 2020-09-01
- 发明人: Paul Parren , Frank Beurskens , Rob N. De Jong , Aran Frank Labrijn , Janine Schuurman
- 申请人: Paul Parren , Frank Beurskens , Rob N. De Jong , Aran Frank Labrijn , Janine Schuurman
- 申请人地址: NL Utrecht
- 专利权人: GENMAB B.V.
- 当前专利权人: GENMAB B.V.
- 当前专利权人地址: NL Utrecht
- 代理机构: Nelson Mullins Riley & Scarborough LLP
- 代理商 Jane E. Remillard, Esq.; Christopher L. Frank
- 优先权: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@5435a152 com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@13546990
- 国际申请: PCT/EP2012/063339 WO 20120706
- 国际公布: WO2013/004842 WO 20130110
- 主分类号: G01N33/53
- IPC分类号: G01N33/53 ; C12N15/00 ; C07K16/00 ; C07K16/28 ; C07K16/36 ; A61K39/00
摘要:
Described herein are polypeptides and related antibodies comprising a variant Fc domain. The variant Fc domain provide for stabilized Fc:Fc interactions when the polypeptide(s), antibody or antibodies are bound to its target, antigen or antigens on the surface of a cell, thus providing for improved effector functions, such as CDC-response.
公开/授权文献
- US20140242075A1 ANTIBODY VARIANTS AND USES THEREOF 公开/授权日:2014-08-28
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