公开(公告)号：US12049512B2

公开(公告)日：2024-07-30

申请号：US16921154

申请日：2020-07-06

申请人： GENMAB B.V.

发明人： Paul Parren ,  Frank Beurskens ,  Rob N. De Jong ,  Aran Frank Labrijn ,  Janine Schuurman

IPC分类号： C07K16/00 ,  C07K16/28 ,  C07K16/36 ,  C12P21/08 ,  A61K39/00 ,  C07K1/00

CPC分类号： C07K16/2896 ,  C07K16/00 ,  C07K16/2863 ,  C07K16/2887 ,  C07K16/36 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/77 ,  C07K2317/90 ,  C07K2317/92

摘要： Described herein are polypeptides and related antibodies comprising a variant Fc domain. The variant Fc domain provide for stabilized Fc:Fc interactions when the polypeptide(s), antibody or antibodies are bound to its target, antigen or antigens on the surface of a cell, thus providing for improved effector functions, such as CDC-response.

公开(公告)号：US20230089196A1

公开(公告)日：2023-03-23

申请号：US17800740

申请日：2021-02-19

申请人： Genmab B.V.

发明人： Ewald T.J. VAN DEN BREMER ,  Sipke SANGERS ,  Demelza WILLEMSZ ,  Richard G. HIBBERT ,  Rob N. DE JONG ,  Søren Skov JENSEN ,  Emil POULSEN

IPC分类号： G01N33/68

摘要： The invention relates to methods for the quantification of glycoproteins in a sample, comprising quantifying said glycoproteins by comparison with an internal standard, wherein said internal standard comprises variant forms of said glycoproteins, wherein said variant forms contain only core Asn-linked GlcNAc moieties.

公开(公告)号：US11180572B2

公开(公告)日：2021-11-23

申请号：US14413178

申请日：2013-07-05

申请人： GENMAB B.V.

发明人： Rob N. De Jong ,  Frank Beurskens ,  Paul Parren ,  Aran Frank Labrijn ,  Janine Schuurman ,  Arjen Vlug ,  Sandra Verploegen

IPC分类号： C07K16/00 ,  A61K39/395 ,  C07K16/28 ,  C07K16/30 ,  C07K16/40 ,  C07K16/32 ,  C07K16/10 ,  C07K16/36 ,  C07K16/12 ,  A61K39/00

摘要： The present invention relates to dimeric proteins comprising amino acids at three different positions which are different from those present in a human IgG1. Six of said dimeric proteins are capable of forming a hexameric structure in solution.

公开(公告)号：US20210324096A1

公开(公告)日：2021-10-21

申请号：US17108373

申请日：2020-12-01

申请人： GENMAB B.V.

发明人： Marije OVERDIJK ,  Kristin STRUMANE ,  Rik RADEMAKER ,  Esther BREIJ ,  Janine SCHUURMAN ,  Paul PARREN

IPC分类号： C07K16/28 ,  C07K16/30 ,  A61P35/00 ,  C12N15/62

摘要： The present invention relates to monospecific or bispecific antibody molecules that specifically bind the human DR5 antigen. The invention relates in particular to DR5-specific antibody molecules of the IgG1 isotype having a mutation in the Fc region that enhances clustering of IgG molecules after cell-surface antigen binding leading to the induction of DR5 signalling, apoptosis and cell death. The invention further relates to a combination of antibody molecules binding different epitopes on DR5. The invention also relates to pharmaceutical compositions containing these molecules and the treatment of cancer using these compositions.

公开(公告)号：US20210238296A1

公开(公告)日：2021-08-05

申请号：US17051205

申请日：2019-05-03

申请人： GENMAB B.V.

发明人： Rob DE JONG ,  Frank BEURSKENS ,  Simone OOSTINDIE ,  Aran Frank LABRIJN ,  Kristin STRUMANE ,  Janine SCHUURMAN ,  Bart-Jan DE KREUK

IPC分类号： C07K16/28 ,  A61K45/06

摘要： Provided herein are combinations of first and second antibodies having modified Fc effector functions resulting from amino acid substitutions in the Fc region, the amino acid substitutions allow for co-dependent activation of effector functions such as CDC and/or ADCC. Also provided are combinations of first and second antibodies having agonistic activity or enhanced agonistic activity resulting from amino acid substitutions in the Fc region where the agonistic activity is co-dependent of both a first and second antibodies.

公开(公告)号：US20210163619A1

公开(公告)日：2021-06-03

申请号：US16921154

申请日：2020-07-06

申请人： GENMAB B.V.

发明人： Paul PARREN ,  Frank BEURSKENS ,  Rob N. DE JONG ,  Aran Frank LABRIJN ,  Janine SCHUURMAN

IPC分类号： C07K16/28 ,  C07K16/36 ,  C07K16/00

摘要： Described herein are polypeptides and related antibodies comprising a variant Fc domain. The variant Fc domain provide for stabilized Fc:Fc interactions when the polypeptide(s), antibody or antibodies are bound to its target, antigen or antigens on the surface of a cell, thus providing for improved effector functions, such as CDC-response.

公开(公告)号：US20230212301A1

公开(公告)日：2023-07-06

申请号：US18055362

申请日：2022-11-14

申请人： Genmab B.V.

发明人： Andreea Ioan ,  Frank Beurskens ,  Rob N. de Jong ,  Janine Schuurman ,  Esther C. W. Breij ,  Isil Altintas ,  Pauline L. de Goeje ,  David Satijn ,  Peter Boross ,  Ugur Sahin ,  Friederike Gieseke ,  Alexander Muik ,  Kristina Schödel

IPC分类号： C07K16/28 ,  C07K16/42 ,  A61P35/00

CPC分类号： C07K16/2878 ,  A61P35/00 ,  C07K16/4208 ,  A61K2039/505

摘要： The present invention relates to antibodies capable of binding to human CD27 and to variants thereof comprising a modified Fc region comprising one or more mutations that enhances the Fc-Fc interaction of the antibody. The invention further provides pharmaceutical compositions comprising the antibodies and use of the antibodies for therapeutic and diagnostic procedures, in particular in cancer therapy.

公开(公告)号：US20210230301A1

公开(公告)日：2021-07-29

申请号：US17012102

申请日：2020-09-04

申请人： GENMAB B.V.

发明人： Rob N. DE JONG ,  Frank BEURSKENS ,  Paul PARREN ,  Aran Frank LABRIJN ,  Janine SCHUURMAN ,  Arjen VLUG ,  Sandra VERPLOEGEN

IPC分类号： C07K16/40 ,  C07K16/28 ,  C07K16/10 ,  C07K16/36 ,  C07K16/00 ,  C07K16/32 ,  C07K16/12

摘要： The present invention relates to dimeric proteins comprising amino acids at three different positions which are different from those present in a human IgG1. Six of said dimeric proteins are capable of forming a hexameric structure in solution.

公开(公告)号：US10647774B2

公开(公告)日：2020-05-12

申请号：US15436583

申请日：2017-02-17

申请人： GENMAB B.V.

发明人： Claudine Brigitte Fernande Vermot-Desroches ,  Olivier Frédéric Subiger ,  Laurence Françoise Jeanne-Marie Bourdin

IPC分类号： C12N15/13 ,  C12N5/10 ,  C07K16/28 ,  C07K16/30 ,  A61K39/00

摘要： Anti-DR5 family member antibodies and bispecific antibodies comprising one or more anti-DR5 family member antibodies are disclosed. These antibodies can be used to trigger cell death on DR5 positive cells.

公开(公告)号：US09611327B2

公开(公告)日：2017-04-04

申请号：US14413194

申请日：2013-07-09

申请人： INTERNATIONAL—DRUG—DEVELOPMENT—BIOTECH

发明人： Claudine Brigitte Fernande Vermot-Desroches ,  Olivier Frédéric Subiger ,  Laurence Françoise Jeanne-Marie Bourdin

IPC分类号： C07K16/28 ,  C07K16/30 ,  A61K39/395 ,  A61K39/00

CPC分类号： C07K16/2878 ,  A61K2039/507 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/75

摘要： Anti-DR5 family member antibodies and bispecific antibodies comprising one or more anti-DR5 family member antibodies are disclosed. These antibodies can be used to trigger cell death on DR5 positive cells.