Invention Grant
- Patent Title: Ester nitrates derivatives of aromatic aldehydes with multiple pharmalogic properties to treat sickle cell disease
-
Application No.: US14913180Application Date: 2014-08-21
-
Publication No.: US10800751B2Publication Date: 2020-10-13
- Inventor: Martin Safo , Jurgen Venitz , Richmond Danso-Danquah , Tanvi Deshpande , Yan Zhang
- Applicant: Virginia Commonwealth University
- Applicant Address: US VA Richmond
- Assignee: Virginia Commonwealth University
- Current Assignee: Virginia Commonwealth University
- Current Assignee Address: US VA Richmond
- Agency: W&C IP
- International Application: PCT/US2014/052099 WO 20140821
- International Announcement: WO2015/027067 WO 20150226
- Main IPC: C07D307/58
- IPC: C07D307/58 ; C07D213/30
Abstract:
The invention provides new aromatic aldehyde compounds that have greater potency in increasing the affinity of Hb for oxygen, greater potency for preventing sickling, and additional pharmacologic properties that ameliorate other symptoms of SCD. The invention further provides methods for treating SCD by providing a subject having SCD with a compound according to the invention.
Public/Granted literature
Information query
