公开(公告)号：US10800751B2

公开(公告)日：2020-10-13

申请号：US14913180

申请日：2014-08-21

Applicant: Virginia Commonwealth University

Inventor： Martin Safo ,  Jurgen Venitz ,  Richmond Danso-Danquah ,  Tanvi Deshpande ,  Yan Zhang

IPC: C07D307/58 ,  C07D213/30

Abstract: The invention provides new aromatic aldehyde compounds that have greater potency in increasing the affinity of Hb for oxygen, greater potency for preventing sickling, and additional pharmacologic properties that ameliorate other symptoms of SCD. The invention further provides methods for treating SCD by providing a subject having SCD with a compound according to the invention.

公开(公告)号：US12065408B2

公开(公告)日：2024-08-20

申请号：US18386724

申请日：2023-11-03

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY ,  IIIExcor Holdings, LLC ,  KING ABDULAZIZ UNIVERSITY ,  CHILDREN'S HOSPITAL OF PHILADELPHIA (CHOP)

Inventor： Martin Safo ,  Yan Zhang ,  Andrew Fleischman ,  David Light ,  Moustafa El-Araby ,  Abdelsattar Omar ,  Osheiza Abdulmalik

IPC: C07D213/30 ,  A61P7/06 ,  C07D239/26

CPC classification number: C07D213/30 ,  A61P7/06 ,  C07D239/26

Abstract: Compounds and methods for preventing and/or treating one or more symptoms of sickle cell diseases (SCD) by administering at least one of the compounds are provided. The compounds are chemically modified to increase bioavailability and activity, e.g., so that the compounds prevent adhesion and sickling of red blood cells (RBCs).

公开(公告)号：US20210053931A1

公开(公告)日：2021-02-25

申请号：US17088063

申请日：2020-11-03

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Martin Safo ,  Yan Zhang ,  Jurgen Venitz ,  Richmond Danso-Danqua ,  Tanvi Deshpande

IPC: C07D307/58 ,  C07D213/30

Abstract: The invention provides new aromatic aldehyde compounds that have greater potency in increasing the affinity of Hb for oxygen, greater potency for preventing sickling, and additional pharmacologic properties that ameliorate other symptoms of SCD. The invention further provides methods for treating SCD by providing a subject having SCD with a compound according to the invention.

公开(公告)号：US10858331B1

公开(公告)日：2020-12-08

申请号：US16987609

申请日：2020-08-07

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Martin Safo ,  Yan Zhang ,  Jurgen Venitz ,  Richmond Danso-Danqua ,  Tanvi Deshpande

IPC: C07D307/58 ,  C07D213/30

Abstract: The invention provides new aromatic aldehyde compounds that have greater potency in increasing the affinity of Hb for oxygen, greater potency for preventing sickling, and additional pharmacologic properties that ameliorate other symptoms of SCD. The invention further provides methods for treating SCD by providing a subject having SCD with a compound according to the invention.

公开(公告)号：US20200369638A1

公开(公告)日：2020-11-26

申请号：US16987609

申请日：2020-08-07

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Martin Safo ,  Yan Zhang ,  Jurgen Venitz ,  Richmond Danso-Danqua ,  Tanvi Deshpande

IPC: C07D307/58 ,  C07D213/30

Abstract: The invention provides new aromatic aldehyde compounds that have greater potency in increasing the affinity of Hb for oxygen, greater potency for preventing sickling, and additional pharmacologic properties that ameliorate other symptoms of SCD. The invention further provides methods for treating SCD by providing a subject having SCD with a compound according to the invention.