公开(公告)号：US20210053931A1

公开(公告)日：2021-02-25

申请号：US17088063

申请日：2020-11-03

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Martin Safo ,  Yan Zhang ,  Jurgen Venitz ,  Richmond Danso-Danqua ,  Tanvi Deshpande

IPC: C07D307/58 ,  C07D213/30

Abstract: The invention provides new aromatic aldehyde compounds that have greater potency in increasing the affinity of Hb for oxygen, greater potency for preventing sickling, and additional pharmacologic properties that ameliorate other symptoms of SCD. The invention further provides methods for treating SCD by providing a subject having SCD with a compound according to the invention.

公开(公告)号：US10800751B2

公开(公告)日：2020-10-13

申请号：US14913180

申请日：2014-08-21

Applicant: Virginia Commonwealth University

Inventor： Martin Safo ,  Jurgen Venitz ,  Richmond Danso-Danquah ,  Tanvi Deshpande ,  Yan Zhang

IPC: C07D307/58 ,  C07D213/30

Abstract: The invention provides new aromatic aldehyde compounds that have greater potency in increasing the affinity of Hb for oxygen, greater potency for preventing sickling, and additional pharmacologic properties that ameliorate other symptoms of SCD. The invention further provides methods for treating SCD by providing a subject having SCD with a compound according to the invention.

公开(公告)号：US10858331B1

公开(公告)日：2020-12-08

申请号：US16987609

申请日：2020-08-07

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Martin Safo ,  Yan Zhang ,  Jurgen Venitz ,  Richmond Danso-Danqua ,  Tanvi Deshpande

IPC: C07D307/58 ,  C07D213/30

Abstract: The invention provides new aromatic aldehyde compounds that have greater potency in increasing the affinity of Hb for oxygen, greater potency for preventing sickling, and additional pharmacologic properties that ameliorate other symptoms of SCD. The invention further provides methods for treating SCD by providing a subject having SCD with a compound according to the invention.

公开(公告)号：US20200369638A1

公开(公告)日：2020-11-26

申请号：US16987609

申请日：2020-08-07

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Martin Safo ,  Yan Zhang ,  Jurgen Venitz ,  Richmond Danso-Danqua ,  Tanvi Deshpande

IPC: C07D307/58 ,  C07D213/30

Abstract: The invention provides new aromatic aldehyde compounds that have greater potency in increasing the affinity of Hb for oxygen, greater potency for preventing sickling, and additional pharmacologic properties that ameliorate other symptoms of SCD. The invention further provides methods for treating SCD by providing a subject having SCD with a compound according to the invention.