发明授权
- 专利标题： Prevention of disulfide bond reduction during recombinant production of polypeptides
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申请号： US16847309申请日： 2020-04-13
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公开(公告)号： US10808037B1公开(公告)日： 2020-10-20
- 发明人: Yung-Hsiang Kao , Michael W. Laird , Melody Trexler Schmidt , Rita L. Wong , Daniel P. Hewitt
- 申请人： Genentech, Inc.
- 申请人地址： US CA South San Francisco
- 专利权人： Genentech, Inc.
- 当前专利权人： Genentech, Inc.
- 当前专利权人地址： US CA South San Francisco
- 代理机构： Morrison & Foerster LLP
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; C07K1/14 ; A61K39/395
摘要：
Provided herein are methods for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.