A catalyst article including a substrate with an inlet end and an outlet end, a first zone and a second zone, where the first zone comprises: a) an ammonia slip catalyst (ASC) bottom layer comprising a platinum group metal on a support; and b) an SCR layer comprising a second SCR catalyst, the SCR layer located over the ASC bottom layer; where the second zone comprises a catalyst (“second zone catalyst”) selected from the group consisting of a diesel oxidation catalyst (DOC) and a diesel exotherm catalyst (DEC); wherein the ASC bottom layer extends into the second zone; and where the first zone is located upstream of the second zone. The ASC bottom layer may include a blend of: (1) the platinum group metal on a support and (2) a first SCR catalyst.