- 专利标题: Method for preparing sucralose-6-acetate in biphasic liquid-liquid system
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申请号: US16300426申请日: 2017-05-18
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公开(公告)号: US10829510B2公开(公告)日: 2020-11-10
- 发明人: Fuxiang Deng , Yu Ding , Wei Xue , Sheng Yu , Wenwu Yan , Ming Yu , Yougui Zhou , Haoran Li
- 申请人: ZHEJIANG NHU COMPANY LTD.
- 申请人地址: CN Shaoxing
- 专利权人: ZHEJIANG NHU COMPANY LTD.
- 当前专利权人: ZHEJIANG NHU COMPANY LTD.
- 当前专利权人地址: CN Shaoxing
- 代理机构: Jacobson Holman PLLC
- 代理商 Jiwen Chen
- 优先权: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@3e702c9a
- 国际申请: PCT/CN2017/084877 WO 20170518
- 国际公布: WO2018/086330 WO 20180517
- 主分类号: C07H13/04
- IPC分类号: C07H13/04 ; C07H1/00
摘要:
The present invention discloses a method for preparing sucralose-6-acetate in a biphasic liquid-liquid system. The method comprises slowly dropwise adding an inert non-polar solvent containing a chlorinating agent to an N,N-dimethyl formamide (DMF) solution of sucrose-6-acetate; then reacting the biphasic liquid-liquid mixture at a certain temperature for 9-20 hours; cooling the system to room temperature after stopping heating, and settling the solution to form layers, an upper layer being an inert non-polar solvent layer, and a lower layer being a DMF solution layer containing the product; hydrolyzing, neutralizing, and filtering the lower layer to obtain a filtrate, and then concentrating the filtrate to obtain a concentrate; dissolving the concentrate in water, and obtaining the product by extraction using ethyl acetate and crystallization, the inert non-polar solvent being an alkane solvent containing 8-18 carbon atoms that is not mutually soluble with DMF. The method has a high product yield, and can significantly reduce the decomposition of DMF, thereby reducing costs.