公开(公告)号：US20240076261A1

公开(公告)日：2024-03-07

申请号：US18270725

申请日：2022-03-24

申请人： ZHEJIANG NHU COMPANY LTD.

发明人： JINLONG LIU ,  SHUMIN LV ,  RUIJUN HU ,  XUEZHONG HE ,  MENGLIANG DU ,  XIAOCHUN WANG ,  ZIYU WANG ,  LANYING LIANG

IPC分类号： C07C51/43

CPC分类号： C07C51/43 ,  C07B2200/13

摘要： The present invention discloses a method for preparing an ibuprofen spherical crystal having high bulk density and a product thereof. The method includes: (1) heating ibuprofen until a molten liquid state is reached; and (2) pressurizing the molten liquid state of ibuprofen, dropping the molten liquid state of ibuprofen into a crystallizer filled with water through a liquid distributor for crystallization under stirring conditions until the molten liquid state of ibuprofen is completely dropped, lowering the rotation speed of stirring to allow crystal growing, and finally, subjecting a resulting crystal slurry to post-treatment to obtain the ibuprofen spherical crystal having high bulk density. The ibuprofen spherical crystal has a bulk density of 0.50-0.70 g/mL, a tap density of 0.63-0.89 g/mL, a median particle size of 300-1,000 μm and an angle of repose of 22-29°. The method of the present invention features that the process thereof is simple, and that no additives are used, such that the method is suitable for industrial production. The ibuprofen spherical crystal prepared has regular crystal habit, smooth crystal surface, good fluidity, high bulk density and high product purity. The quality of a product meets requirements of CP2020, EP9.8, USP41 and other pharmacopoeias.

公开(公告)号：US11632970B2

公开(公告)日：2023-04-25

申请号：US16067528

申请日：2016-12-08

申请人： ZHEJIANG NHU COMPANY LTD. ,  ZHEJIANG UNIVERSITY

发明人： Jiandong Li ,  Zhirong Chen ,  Hong Yin ,  Xiaoyong Zhu ,  Dan Qiu ,  Lifang Shi ,  Dongming Shi ,  Yong Qi

IPC分类号： A23K20/174 ,  A23K40/30 ,  A23P10/30 ,  A23L33/15 ,  A61K9/14 ,  A61K31/015

摘要： The present invention discloses a method for preparation of vitamin and carotenoid powder; the vitamin and carotenoid powder comprises vitamin, carotenoid microcapsule and physical gel protection film covered on the surface of the vitamin and carotenoid microcapsule; the physical gel protection film is made from super-molecular system; the super-molecular system comprises the following constituents of parts in weight: vegetable oil: 6-30 parts; gel: 0.5-3 parts and antioxidant: 0.5-3 parts. The hot super-molecular solution is sprayed on the surface of cold vitamin and carotenoid microcapsule during preparation to form a specific 3D network structure that is used to bind the liquefied vegetable oil to form a physical gel protection film; the physical gel protection film has improved product storage stability as well as the its stability for application in feedstuff, food and health care products.

公开(公告)号：US09567440B2

公开(公告)日：2017-02-14

申请号：US14655326

申请日：2013-10-29

申请人： ZHEJIANG NHU SPECIAL MATERIALS CO., LTD. ,  ZHEJIANG UNIVERSITY ,  SHANGYU NHU BIOLOGICAL CHEMICAL CO., LTD. ,  ZHEJIANG NHU COMPANY LTD.

发明人： Zhirong Chen ,  Woyuan Li ,  Haoran Li ,  Ming Lian ,  Hong Yin ,  Guiyang Zhou ,  Xinfeng Zheng

IPC分类号： C08G75/16 ,  C08G75/00 ,  C08G75/02

CPC分类号： C08G75/16 ,  C08G75/02

摘要： The present invention discloses a fiber-grade polyphenylene sulfide resin synthesis method, taking sodium bisulfide and p-dichlorobenzene as raw materials, N-methyl pyrrolidone as the solvent and C5-C6 fatty acid salt formed through dehydration to C5-C6 fatty acid and sodium hydroxide as the polymerization additive for synthesis through polymerization. White polyphenylene sulfide resin is obtained through acidification and washing of reaction slurry. In view of the fact that MFR is below 125 g/10 min, weight-average molecular weight as measured by GPC is over 4.2×104, and whiteness is over 90, it can satisfy requirements for fiber polyphenylene sulfide resin. C5-C6 fatty acid salt according to the method of the present invention has a higher solubility in NMP, which can better promote polymerization. It is to be fully diverted into the filtrate after filter prior to conversion into free fatty acid again through acidification with hydrochloric acid. C5-C6 fatty acid is available for azeotropy with water, which has a limited solubility in water. Therefore, it is applicable to recycle C5-C6 fatty acid from the filtrate through azeotropy with water, and thereby solve the problem with separation of additive and sodium chloride that are soluble in water.

摘要翻译： 本发明公开了以二硫化二钠和对二氯苯为原料的纤维级聚苯硫醚树脂的合成方法，将N-甲基吡咯烷酮作为溶剂和通过脱水形成C5-C6脂肪酸和 氢氧化物作为通过聚合合成的聚合添加剂。 白色聚苯硫醚树脂通过反应浆液的酸化和洗涤得到。 鉴于MFR低于125g / 10min，通过GPC测得的重均分子量超过4.2×104，白度超过90，可以满足纤维聚苯硫醚树脂的要求。 根据本发明方法的C5-C6脂肪酸盐在NMP中的溶解度较高，可以更好地促进聚合。 过滤后将其全部转入滤液，然后再用盐酸酸化再转化成游离脂肪酸。 C5-C6脂肪酸可与水共沸，其在水中的溶解度有限。 因此，适用于通过与水共沸从滤液中回收C5-C6脂肪酸，从而解决了可溶于水的添加剂和氯化钠的分离问题。

公开(公告)号：US20120018912A1

公开(公告)日：2012-01-26

申请号：US13259291

申请日：2010-03-18

申请人： Zhirong Chen ,  Jianfeng Chen ,  Hong Yin ,  Hong Zhao ,  Dan Qiu ,  Lifang Shi ,  Jiandong Li ,  Guangwen Chu ,  Lei Shao

发明人： Zhirong Chen ,  Jianfeng Chen ,  Hong Yin ,  Hong Zhao ,  Dan Qiu ,  Lifang Shi ,  Jiandong Li ,  Guangwen Chu ,  Lei Shao

IPC分类号： B29B9/12

CPC分类号： B01J13/043 ,  A23K20/179 ,  A23L5/44 ,  A23L33/10 ,  A23L33/105 ,  A23P10/30 ,  A23V2002/00 ,  A61K8/0241 ,  A61K8/11 ,  A61K8/31 ,  A61K8/35 ,  A61K31/01 ,  A61K31/122 ,  A61K2800/412 ,  A61Q19/00 ,  C09B61/00 ,  C09B67/0097 ,  A23V2250/211 ,  A23V2200/224

摘要： A method of preparing nano-dispersed high-all-trans-carotenoid microcapsules is provided, comprising: preparing 10-20% carotenoid suspension by milling the high-all trans-carotenoid crystals with dichloromethane until the particle size thereof is in the range of 2-5 μm, then supplying the suspension together with preheated dichloromethane of another pass into a dissolving tank to obtain a solution of 0.5-2%; delivering the solution together with ethanol or isopropanol into a crystallization device having high gravity rotating packed bed simultaneously and continuously, and then into a wiped-film evaporator for desolvation until the solid content is 10-20%, then a transparent alcohol dispersion of carotenoid is obtained; mashing the alcohol dispersion together with an aqueous solution containing an antioxidant and protective colloid and spray drying to obtain nano-dispersed high-all-trans-carotenoid microcapsules. As the crystals are nano-dispersed and the content of trans-isomer is more than 90%, the carotenoid microcapsules of present inventions exhibit high bioavailability.

摘要翻译： 提供了一种制备纳米分散高全反式类胡萝卜素微胶囊的方法，包括：通过用二氯甲烷研磨高全反式类胡萝卜素晶体制备10-20％的类胡萝卜素悬浮液，直到其粒径在2 -5μm，然后将悬浮液与另一道次的预热二氯甲烷一起供入溶解槽中，得到0.5-2％的溶液; 将溶液与乙醇或异丙醇一起输送到具有高重力旋转填充床的结晶装置中，同时且连续地进行，然后进入擦膜蒸发器进行去溶剂化直到固体含量为10-20％，然后将类胡萝卜素的透明醇分散体 获得; 将醇分散体与含有抗氧化剂和保护胶体的水溶液一起糖化并喷雾干燥，得到纳米分散的高全反式类胡萝卜素微胶囊。 由于晶体是纳米分散的并且反式异构体的含量大于90％，本发明的类胡萝卜素微胶囊显示出高的生物利用度。

公开(公告)号：US20230406807A1

公开(公告)日：2023-12-21

申请号：US18240466

申请日：2023-08-31

申请人： ZHEJIANG NHU COMPANY LTD. ,  ZHEJIANG NHU SPECIAL MATERIALS CO., LTD.

发明人： Lei WU ,  Kunpeng CHENG ,  Xueming LI ,  Runrun HONG ,  Qing'ai SHI ,  Chuang WANG ,  Guodong HUANG ,  Guiyang ZHOU

IPC分类号： C07C67/035 ,  B01J19/00 ,  B01J21/06 ,  B01J23/04

CPC分类号： C07C67/035 ,  B01J19/0006 ,  B01J21/066 ,  B01J23/04

摘要： A method and apparatus for preparing methyl methacrylate (MMA) are provided. The method includes an aldol condensation reaction, a first distillation, a second distillation, a third distillation, a phase splitting, and a fourth distillation. Through the control of the process, the aldol condensation reaction can be performed when methyl propionate is used as the ninth material stream and formalin solution is used as the fifteenth stream material, MMA is obtained as the final product from the third material stream, and the waste with low content of residual formaldehyde is recovered from the eighth material stream.

公开(公告)号：US20220371992A1

公开(公告)日：2022-11-24

申请号：US17618887

申请日：2020-11-17

申请人： ZHEJIANG NHU COMPANY LTD. ,  ZHEJIANG NHU PHARMACEUTICAL CO., LTD. ,  SHANGYU NHU BIO-CHEM CO., LTD.

发明人： Xiaoxiang HE ,  Junhua PENG ,  Xianghua YAO ,  Songhua XU ,  Lihuan CHENG ,  Yinbing WANG ,  Yinjiang SONG ,  Lei WANG

IPC分类号： C07C303/44 ,  C07C303/22

摘要： The present disclosure relates to a method for preparing taurine and a method for recovering a mother liquor thereof. The method for recovering the taurine mother liquor comprises: providing a taurine mother liquor, and mixing the taurine mother liquor and a treating agent to obtain a solid-containing suspension, wherein the treating agent is a water-soluble organic solvent or a mixture of the water-soluble organic solvent and water; filtering the suspension to obtain a first solid product and a first filtrate; and dissolving the first solid product with an ammonia source, and then filtering same to obtain a second solid product and a second filtrate.

公开(公告)号：US11180440B2

公开(公告)日：2021-11-23

申请号：US16954774

申请日：2018-11-30

申请人： Zhejiang Nhu Company Ltd. ,  Zhejiang University ,  Shandong Nhu Amino Acid Co., Ltd. ,  Shandong Nhu Fine Chemical Science and Technology Company Ltd.

发明人： Zhirong Chen ,  Jianyong Mao ,  Baishan Hu ,  Guanbing Li ,  Haoran Li ,  Yu Wang ,  Yingkuo Yang ,  Qing Liu ,  Jiyu Tang ,  Weiyong Chen

IPC分类号： C07C209/52 ,  B01J23/78 ,  B01J35/04 ,  C07C209/48

摘要： The present disclosure relates to a method for preparing isophorone diamine by means of a hydrogenation reduction of isophorone nitrile imine. The hydrogenation reduction is continuously carried out in a multi-stage bubble column reactor loaded with a supported alkaline cobalt-based catalyst, wherein isophorone nitrile imine is successively in countercurrent contact with hydrogen in each stage of the reactor to carry out a hydrogenation reduction reaction, so as to obtain the isophorone diamine. The preparation method solves the problem of back-mixing, and further improves the conversion rate and the cis/trans ratio of the product.

公开(公告)号：US20210324391A1

公开(公告)日：2021-10-21

申请号：US17271356

申请日：2019-05-31

申请人： ZHEJIANG NHU COMPANY LTD. ,  HEILONGJIANG NHU BIOTECHNOLOGY COMPANY TLD. ,  SHANGYU NHU BIOLOGICAL CHEMICAL CO., LTD. ,  ZHEJIANG UNIVERSITY

发明人： Hongwei Yu ,  Shenfeng YUAN ,  Yongqiang ZHU ,  Kai YU ,  Zhirong CHEN ,  Yong LI ,  Guisheng QIU ,  Xiaoqing LIU

IPC分类号： C12N15/74 ,  C07K14/245 ,  C12P7/66 ,  C12N1/20

摘要： A recombinant microorganism, a preparation method thereof and its application in the production of coenzyme Q10. Specifically, the present disclosure provides a method of exogenously introducing a gene encoding the global regulatory protein irrE to construct a recombinant microorganism. This recombinant microorganism is suitable for producing coenzyme Q10 by fermentation method, and is particularly suitable for producing oxidized coenzyme Q10. The recombinant microorganism of the present disclosure has stress resistance, and has good tolerance against harsh environments including high osmotic pressure and high redox potential, thus making it possible to significantly increase the yield of coenzyme Q10, especially the yield of oxidized coenzyme Q10.

公开(公告)号：US20210147350A1

公开(公告)日：2021-05-20

申请号：US17263362

申请日：2019-08-27

申请人： ZHEJIANG NHU COMPANY LTD. ,  ZHEJIANG UNIVERSITY ,  SHANDONG NHU AMINO ACID CO., LTD.

发明人： Zhirong Chen ,  Hong Yin ,  Baishan Hu ,  Zhengjiang Wang ,  Zhixuan Wang ,  Cong Chen ,  Guisheng Qiu ,  Qichuan Li ,  Qingai Shi

IPC分类号： C07C319/20 ,  C07C319/28 ,  C07C323/52 ,  B01J19/24

摘要： Provided by the present disclosure are a method and a device for preparing 2-hydroxy-4-methylthiobutyric acid and intermediates thereof; the intermediates for preparing 2-hydroxy-4-methylthiobutyric acid comprise 3-methylthiopropionaldehyde and 2-hydroxy-4-methylthiobutyronitrile. The method for preparing 2-hydroxy-4-methylthiobutyric acid provided by the present disclosure comprises: step (1), a step of reacting acrolein with methyl mercaptan to prepare 3-methylthiopropionaldehyde; step (2), a step of reacting 3-methylthiopropionaldehyde with hydrocyanic acid to prepare 2-hydroxy-4-methylthiobutyronitrile; and step (3), a step of hydrating 2-hydroxy-4-methylthiobutyronitrile by using sulfuric acid and then hydrolyzing to prepare 2-hydroxy-4-methylthiobutyric acid; wherein in steps (1), (2) and (3), the reaction status of the materials is detected online, and the proportions of the materials are controlled according to the detection results such that reactions are performed completely

公开(公告)号：US10974225B1

公开(公告)日：2021-04-13

申请号：US16919092

申请日：2020-07-01

申请人： ZHEJIANG NHU COMPANY LTD. ,  ZHEJIANG UNIVERSITY ,  SHANDONG NHU PHARMACEUTICAL CO., LTD.

发明人： Haoran Li ,  Xiao Ma ,  Yong Wang ,  Baishan Hu ,  Dan Qiu ,  Jianyong Mao ,  Bing Lu ,  Shanjun Mao ,  Lili Yu ,  Qichuan Li

IPC分类号： B01J23/00 ,  B01J23/889 ,  C07C29/56 ,  B01J23/881 ,  B01J37/02 ,  B01J37/08 ,  B01J35/04 ,  B01J21/06

摘要： The present disclosure belongs to the technical field of catalysis, and particularly relates to a metal oxide coated ceramic corrugated plate catalyst, its preparation method and application thereof in preparation of key intermediates of citral. The catalyst consists of a ceramic corrugated plate carrier and a metal oxide active layer coated on a surface of the carrier, wherein the metal oxide active layer is a metal oxide formed by active ingredient titanium and at least four other metal elements selected from vanadium, chromium, manganese, iron, zirconium, niobium and molybdenum.