- 专利标题： Aryl or heteroaryl triazolone derivatives or salts thereof, or pharmaceutical compositions comprising the same
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申请号： US16721020申请日： 2019-12-19
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公开(公告)号： US10899719B2公开(公告)日： 2021-01-26
- 发明人: Tae Dong Han , Hee Jae Tak , Eun Kyung Kim , Su Bin Choi , Dong Hoon Kim , Sol Park , Eun Hye Jung , Hyun Ho Choi , Tae Wang Kim , Mi Kyeong Ju , Na Ry Ha
- 申请人： YUHAN CORPORATION
- 申请人地址： KR Seoul
- 专利权人： YUHAN CORPORATION
- 当前专利权人： YUHAN CORPORATION
- 当前专利权人地址： KR Seoul
- 代理机构： Foley & Lardner LLP
- 优先权： KR10-2018-0032554 20180321
- 主分类号： C07D403/04
- IPC分类号： C07D403/04 ; C07D249/08 ; C07D401/04 ; C07D417/04 ; C07D409/10 ; C07D405/10 ; C07D407/14 ; C07D401/10 ; C07D403/10 ; C07D401/14 ; C07D405/14 ; C07D417/14 ; C07D413/14 ; C07D413/10 ; C07D417/10 ; C07D249/12 ; C07D403/14
摘要：
The present technology provides aryl or heteroaryl triazolone derivatives or pharmaceutically acceptable salts thereof, preparation processes thereof, pharmaceutical compositions comprising the same, and the use thereof. The aryl or heteroaryl triazolone derivatives or their pharmaceutically acceptable salts exhibit selective inhibitory activity on VAP-1 and therefore can be usefully applied, e.g., for the treatment and prophylaxis of nonalcoholic hepatosteatosis (NASH).
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