Invention Grant
- Patent Title: Multiplexed genome editing
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Application No.: US15766551Application Date: 2016-10-07
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Publication No.: US10959413B2Publication Date: 2021-03-30
- Inventor: George M. Church , Luhan Yang , Marc Guell
- Applicant: President and Fellows of Harvard College
- Applicant Address: US MA Cambridge
- Assignee: President and Fellows of Harvard College
- Current Assignee: President and Fellows of Harvard College
- Current Assignee Address: US MA Cambridge
- Agency: Banner & Witcoff, Ltd.
- International Application: PCT/US2016/055916 WO 20161007
- International Announcement: WO2017/062723 WO 20170413
- Main IPC: C12N15/63
- IPC: C12N15/63 ; C07H21/02 ; C07H21/04 ; A01K67/027 ; C12N15/113 ; C12N15/85 ; C12N7/00 ; C12N9/22 ; C12N15/11 ; C12N15/90
Abstract:
A method of modulating some or all copies of a gene in a cell is provided including introducing into a cell one or more ribonucleic acid (RNA) sequences that comprise a portion that is complementary to all or a portion of each of the one or more target nucleic acid sequences, and a nucleic acid sequence that encodes a Cas protein and maintaining the cells under conditions in which the Cas protein is expressed and the Cas protein binds and modulates the one or more target nucleic acid sequences in the cell.
Public/Granted literature
- US20180288983A1 Multiplexed Genome Editing Public/Granted day:2018-10-11
Information query
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