Invention Grant
- Patent Title: Veto cells generated from memory T cells
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Application No.: US16313486Application Date: 2017-06-27
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Publication No.: US10961504B2Publication Date: 2021-03-30
- Inventor: Yair Reisner , Noga Or-Geva , Rotem Gidron Budovsky , Esther Bachar-Lustig , Assaf Lask , Sivan Kagan
- Applicant: Yeda Research and Development Co. Ltd.
- Applicant Address: IL Rehovot
- Assignee: Yeda Research and Development Co. Ltd.
- Current Assignee: Yeda Research and Development Co. Ltd.
- Current Assignee Address: IL Rehovot
- International Application: PCT/IL2017/050716 WO 20170627
- International Announcement: WO2018/002924 WO 20180104
- Main IPC: C12N5/0783
- IPC: C12N5/0783 ; A61K35/17 ; A61K39/00 ; C12N5/00 ; A61K35/12

Abstract:
A method of generating an isolated population of non graft versus host disease (GvHD) inducing cells comprising a central memory T-lymphocyte (Tcm) phenotype, the cells being tolerance inducing cells and/or endowed with anti-disease activity, and capable of homing to the lymph nodes following transplantation is disclosed. The method comprising: (a) providing a population of at least 70% memory T cells; (b) contacting the population of memory T cells with an antigen or antigens so as to allow enrichment of antigen reactive cells; and (c) culturing the cells resulting from step (b) in the presence of cytokines so as to allow proliferation of cells comprising the Tcm phenotype. Cells generated by the method, pharmaceutical compositions and methods of treatment are also disclosed.
Public/Granted literature
- US20190316087A1 VETO CELLS GENERATED FROM MEMORY T CELLS Public/Granted day:2019-10-17
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