The microneedle sheet according to an embodiment comprises a plurality of microneedles formed on a sheet generally along a main surface of the sheet; a bending resistance of the sheet as measured in accordance with a 45° cantilever method defined by JIS L 1096:2010 is 4.2 cm to 12.5 cm; and a material of the sheet is a biodegradable polymer. The microneedles rise from the main surface when the sheet is bent, and the raised microneedles pierce the skin.