公开(公告)号：US10307381B2

公开(公告)日：2019-06-04

申请号：US15518847

申请日：2015-10-13

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Junji Noguchi ,  Eisuke Hatanaka ,  Hisakazu Kurita ,  Ryusuke Fudoji ,  Yasunari Michinaka

IPC: A61K31/485 ,  A61K9/70 ,  A61K47/10 ,  A61K31/00 ,  A61K47/06 ,  C08F226/02 ,  C08F226/10 ,  C08K5/092

Abstract: A patch including: a support; and an adhesive layer disposed on at least one surface of the support, in which the adhesive layer includes: at least one selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof; a higher aliphatic alcohol; and a non-cross-linking polyvinylpyrrolidone that does not contain vinyl acetate as a constituent monomer thereof.

公开(公告)号：US10987502B2

公开(公告)日：2021-04-27

申请号：US16061834

申请日：2016-12-06

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Ryusuke Fudoji ,  Naoki Yamamoto

IPC: A61M37/00 ,  C08L67/04 ,  C08G69/10

Abstract: The microneedle sheet according to an embodiment comprises a plurality of microneedles formed on a sheet generally along a main surface of the sheet; a bending resistance of the sheet as measured in accordance with a 45° cantilever method defined by JIS L 1096:2010 is 4.2 cm to 12.5 cm; and a material of the sheet is a biodegradable polymer. The microneedles rise from the main surface when the sheet is bent, and the raised microneedles pierce the skin.

公开(公告)号：US09717893B2

公开(公告)日：2017-08-01

申请号：US14767138

申请日：2014-02-12

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Ryusuke Fudoji ,  Makoto Ogura

IPC: A61M37/00

CPC classification number: A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0053 ,  A61M2037/0061

Abstract: A microneedle array in accordance with one embodiment comprises at least a first microneedle and a second microneedle that are inclined with respect to a support face. A tip of the first microneedle points in a first direction, and a tip of the second microneedle points in a second direction different from the first direction. The first microneedle in contact with skin is stuck into the skin while being moved along a surface of the skin in the first direction. The second microneedle in contact with the skin is stuck into the skin while being moved along the surface of the skin in the second direction.