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公开(公告)号：US11007358B2
公开(公告)日：2021-05-18
申请号：US16325325
申请日：2017-08-30
发明人： Naoki Yamamoto , Seiji Tokumoto
摘要： A microneedle sheet is disclosed that comprises a plurality of microneedles formed on a sheet generally along a principal surface of the sheet, wherein the microneedles contain a water-soluble polysaccharide and water, the water content is 1 mass % or more and less than 19 mass % based on the total mass of the microneedles, and the microneedles are raised from the principal surface by bending the sheet.
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公开(公告)号：US11642505B2
公开(公告)日：2023-05-09
申请号：US16767290
申请日：2018-11-06
发明人： Takuya Tajima , Naoki Yamamoto , Seiji Tokumoto
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61M2205/0216
摘要： An application kit according to one embodiment includes: a cartridge including a sheet member; and an applicator being connectable to the cartridge. The cartridge includes a bending portion configured to bend the sheet member and a cartridge-side connector configured to be detachably connected to the applicator. The applicator includes: an applicator body; an applicator-side connector provided to a bottom portion of the applicator body; a cap provided above the applicator body and being movable along a height direction of the applicator body; and an elastic member extending along the height direction between the applicator body and the cap and configured to apply, to the cap, an elastic force that acts in a direction away from the bottom portion.
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公开(公告)号：US10039911B2
公开(公告)日：2018-08-07
申请号：US14899148
申请日：2014-06-17
发明人： Naoki Yamamoto , Makoto Ogura
摘要： An applicator of one aspect for applying microneedles to skin includes a resistive portion configured to apply resistance against movement of a microneedle sheet having the plurality of microneedles formed along a main surface of the sheet, and a bending portion configured to bend the microneedle sheet passed through the resistive portion to raise the microneedle from the main surface.
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公开(公告)号：US11141576B2
公开(公告)日：2021-10-12
申请号：US16471290
申请日：2017-12-15
发明人： Takuya Tajima , Naoki Yamamoto , Seiji Tokumoto
IPC分类号： A61M37/00
摘要： An applicator of one embodiment is for applying a sheet member to skin. The applicator includes: a body including a bottom plate configured to face the skin and a bending portion provided to the bottom plate; a cap being movable along a slide direction substantially orthogonal to the bottom plate; and an elastic member configured to extend along the slide direction between the body and the cap. The elastic member applies, to the cap, elastic force that acts in a direction away from the bottom plate, the cap being movable toward the bottom plate against the elastic force. The bending portion bends the sheet member that has advanced thereto in a pressed state in which the cap has been moved toward the bottom plate, thereby applying the sheet member to the skin.
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公开(公告)号：US10987502B2
公开(公告)日：2021-04-27
申请号：US16061834
申请日：2016-12-06
发明人： Ryusuke Fudoji , Naoki Yamamoto
摘要： The microneedle sheet according to an embodiment comprises a plurality of microneedles formed on a sheet generally along a main surface of the sheet; a bending resistance of the sheet as measured in accordance with a 45° cantilever method defined by JIS L 1096:2010 is 4.2 cm to 12.5 cm; and a material of the sheet is a biodegradable polymer. The microneedles rise from the main surface when the sheet is bent, and the raised microneedles pierce the skin.
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公开(公告)号：US10589077B2
公开(公告)日：2020-03-17
申请号：US15532836
申请日：2015-12-04
发明人： Makoto Ogura , Naoki Yamamoto , Takashi Kumon
IPC分类号： A61M37/00
摘要： A microneedle device system includes a microneedle device having a sheet-like microneedle having a sheet in which one surface is a skin contact surface and the other surface is a rear surface, and in which a plurality of microneedles are formed substantially along a surface of the sheet, and in which the microneedles in the skin piercing region are raised from the skin contact surface so as to be capable of piercing skin if the sheet is bent in a thickness direction, an adhesive layer that is disposed on the sheet-like microneedle, and a liner that is attached to the adhesive layer so as to be releasable therefrom, and an auxiliary tool having a bending portion which bends the microneedle device in the thickness direction, and on which the microneedle device is mounted so as to be movable along the bending portion.
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公开(公告)号：US09849272B2
公开(公告)日：2017-12-26
申请号：US14899146
申请日：2014-06-17
发明人： Naoki Yamamoto , Makoto Ogura
CPC分类号： A61M37/0015 , A61M25/002 , A61M35/00 , A61M37/00 , A61M2025/0266 , A61M2037/0023
摘要： An applicator of one aspect for applying a sheet member to skin includes a body having a bottom surface facing the skin and a first guide configured to guide the sheet member to a space between the skin and the bottom surface, in which the sheet member is applied to the skin after being folded in the space.
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公开(公告)号：US20150157840A1
公开(公告)日：2015-06-11
申请号：US14407258
申请日：2013-06-11
发明人： Kazuya Kominami , Shinpei Nishimura , Seiji Tokumoto , Makoto Ogura , Toshiyuki Matsudo , Naoki Yamamoto
CPC分类号： A61M37/0015 , A61M37/0092 , A61M2037/0007 , A61M2037/0023 , A61M2037/0061 , A61N1/325 , A61N2/002 , A61N2/004
摘要： A microneedle sheet according to an embodiment comprises a plurality of microneedles formed on a sheet substantially along a principal surface of the sheet. The sheet is bent to raise the microneedles from the principal surface, and the raised microneedles pierce a skin.
摘要翻译： 根据一个实施方案的微针片包括形成在基本上沿着片材的主表面的片材上的多个微针。 弯曲片从主表面抬起微针，凸起的微针刺穿皮肤。
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