- Patent Title: Method of producing in vitro testicular constructs and uses thereof
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Application No.: US15294154Application Date: 2016-10-14
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Publication No.: US10993433B2Publication Date: 2021-05-04
- Inventor: Samuel Pendergraft , Hooman Sadri-Ardekani , Anthony Atala , Colin Bishop
- Applicant: Wake Forest University Health Sciences
- Applicant Address: US NC Winston-Salem
- Assignee: Wake Forest University Health Sciences
- Current Assignee: Wake Forest University Health Sciences
- Current Assignee Address: US NC Winston-Salem
- Agency: Myers Bigel, P.A
- Main IPC: C12N5/22
- IPC: C12N5/22 ; A01N1/02 ; C12N5/071
Abstract:
A cell composition composed of spermatogonial stem cells, Sertoli cells, Leydig cells and optionally peritubular cells, is provided, as is a culture composition, artificial testicular construct, hydrogel composition, and device containing the same. A method for using the device as a physiologically relevant in vitro model of human testicular function to screen compounds for pharmacological or toxicological activity is also provided.
Public/Granted literature
- US20170107483A1 METHOD OF PRODUCING IN VITRO TESTICULAR CONSTRUCTS AND USES THEREOF Public/Granted day:2017-04-20
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