公开(公告)号：US11732241B2

公开(公告)日：2023-08-22

申请号：US15768293

申请日：2016-10-14

Applicant: Wake Forest University Health Sciences

Inventor： Anthony Atala ,  Colin Bishop ,  Ivy Mead

IPC: C12N5/071 ,  C12M3/00 ,  G01N33/50 ,  B33Y10/00

CPC classification number: C12N5/0671 ,  B33Y10/00 ,  C12M21/08 ,  C12N5/067 ,  G01N33/5088 ,  C12N2502/14 ,  C12N2503/02

Abstract: Provided herein are cell compositions useful for making artificial liver constructs. The cell composition my include, in combination, (a) hepatocyte cells, (b) Kuppfer cells, (c) hepatic stellate cells, (d) sinusoidal endothelial cells, and (e) cholangiocyte cells.

公开(公告)号：US20180320141A1

公开(公告)日：2018-11-08

申请号：US15768293

申请日：2016-10-14

Applicant: Wake Forest University Health Sciences

Inventor： Anthony Atala ,  Colin Bishop ,  Ivy Mead

IPC: C12N5/071 ,  C12M3/00 ,  G01N33/50 ,  B33Y10/00

CPC classification number: C12N5/0671 ,  B33Y10/00 ,  C12M21/08 ,  C12N2502/14 ,  C12N2503/02 ,  G01N33/5088

Abstract: Provided herein are cell compositions useful for making artificial liver constructs. The cell composition my include, in combination, (a) hepatocyte cells, (b) Kuppfer cells, (c) hepatic stellate cells, (d) sinusoidal endothelial cells, and (e) cholangiocyte cells.

公开(公告)号：US10993433B2

公开(公告)日：2021-05-04

申请号：US15294154

申请日：2016-10-14

Applicant: Wake Forest University Health Sciences

Inventor： Samuel Pendergraft ,  Hooman Sadri-Ardekani ,  Anthony Atala ,  Colin Bishop

IPC: C12N5/22 ,  A01N1/02 ,  C12N5/071

Abstract: A cell composition composed of spermatogonial stem cells, Sertoli cells, Leydig cells and optionally peritubular cells, is provided, as is a culture composition, artificial testicular construct, hydrogel composition, and device containing the same. A method for using the device as a physiologically relevant in vitro model of human testicular function to screen compounds for pharmacological or toxicological activity is also provided.

公开(公告)号：US20170107483A1

公开(公告)日：2017-04-20

申请号：US15294154

申请日：2016-10-14

Applicant: Wake Forest University Health Sciences

Inventor： Samuel Pendergraft ,  Hooman Sadri-Ardekani ,  Anthony Atala ,  Colin Bishop

IPC: C12N5/076 ,  A01N1/02

CPC classification number: A01N1/021 ,  A01N1/0221 ,  C12N5/0697 ,  C12N2506/246 ,  C12N2510/04 ,  C12N2533/90

Abstract: A cell composition composed of spermatogonial stem cells, Sertoli cells, Leydig cells and optionally peritubular cells, is provided, as is a culture composition, artificial testicular construct, hydrogel composition, and device containing the same. A method for using the device as a physiologically relevant in vitro model of human testicular function to screen compounds for pharmacological or toxicological activity is also provided.