Invention Grant
- Patent Title: Anti-BCMA chimeric antigen receptor
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Application No.: US16197565Application Date: 2018-11-21
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Publication No.: US11084880B2Publication Date: 2021-08-10
- Inventor: Jennifer Brogdon , Eugene Choi , Hilmar Erhard Ebersbach , David Jonathan Glass , Heather Huet , Carl H. June , Joan Mannick , Michael C. Milone , Leon Murphy , Gabriela Plesa , Celeste Richardson , Marco Ruella , Reshma Singh , Yongqiang Wang , Qilong Wu
- Applicant: Novartis AG , The Trustees of the University of Pennsylvania
- Applicant Address: CH Basel; US PA Philadelphia
- Assignee: Novartis AG,The Trustees of the University of Pennsylvania
- Current Assignee: Novartis AG,The Trustees of the University of Pennsylvania
- Current Assignee Address: CH Basel; US PA Philadelphia
- Agency: Lando & Anastasi, LLP
- Priority: WOPCT/CN2014/082586 20140721,WOPCT/CN2014/090501 20141106
- Main IPC: C07K16/28
- IPC: C07K16/28 ; C07K14/705 ; C07K19/00 ; C07K14/725 ; A61P35/00 ; A61K39/395 ; A61K35/12 ; A61K38/17 ; C07K14/715 ; C07H21/04 ; C12N15/63 ; C12N5/00
Abstract:
The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.
Public/Granted literature
- US20190153061A1 TREATMENT OF CANCER USING 5 HUMANIZED ANTI-BCMA CHIMERIC ANTIGEN RECEPTOR Public/Granted day:2019-05-23
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