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公开(公告)号:US11591404B2
公开(公告)日:2023-02-28
申请号:US16884867
申请日:2020-05-27
发明人: Jennifer Brogdon , Saar Gill , David Jonathan Glass , Saad Kenderian , Andreas Loew , Joan Mannick , Michael C. Milone , Leon Murphy , David L. Porter , Marco Ruella , Yongqiang Wang , Qilong Wu , Jiquan Zhang
IPC分类号: C07K16/28 , C07K16/24 , C12N5/0783 , A61K39/00
摘要: The invention provides compositions and methods for treating diseases associated with expression of CD123. The invention also relates to chimeric antigen receptor (CAR) specific to CD123, vectors encoding the same, and recombinant cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified cell expressing a CAR that comprises a CD123 binding domain.
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公开(公告)号:US10577417B2
公开(公告)日:2020-03-03
申请号:US15511973
申请日:2015-09-17
发明人: Gregory Beatty , Boris Engels , Neeraja Idamakanti , Carl H. June , Andreas Loew , Michael C. Milone , Huijuan Song , Enxiu Wang , Qilong Wu
IPC分类号: A61K35/17 , C07K14/705 , C07K16/28 , C07K16/30 , C07K14/725 , C07K14/74 , C12N5/0783
摘要: The present invention provides compositions and methods for regulating the specificity and activity of immune effector cells for use in immunotherapy. In one embodiment, the invention provides a type of chimeric antigen receptor (CAR) wherein the CAR is termed a “NKR-CAR” which is a CAR design comprising a component of a receptor naturally found on natural killer (NK) cells. In one embodiment, the NK receptor includes but is not limited to a naturally occurring activating and inhibitory receptor of NK cells known as a killer cell immunoglobulin-like receptor (KIR).
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公开(公告)号:US20230052970A1
公开(公告)日:2023-02-16
申请号:US17937488
申请日:2022-10-03
发明人: Jennifer Brogdon , Hilmar Erhard Ebersbach , David Glass , Thomas Huber , Julia Jascur , Carl H. June , Jihyun Lee , Joan Mannick , Michael C. Milone , Leon Murphy , Avery D. Posey , Huijuan Song , Yongqiang Wang , Lai Wei , Qilong Wu , Qiumei Yang , Jiquan Zhang
IPC分类号: C07K16/28 , A61K35/17 , C07K16/30 , C07K14/705 , A61P35/02 , A61P35/00 , A61K48/00 , C07K14/725 , C12N15/86
摘要: The invention provides compositions and methods for treating diseases associated with expression of a tumor antigen as described herein. The invention also relates to nucleic acids comprising a truncated PGK promoter operably linked to a chimeric antigen receptor (CAR) specific to a tumor antigen as described herein, vectors encoding the same, and recombinant T cells comprising the CARs of the present invention. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises an antigen binding domain that binds to a tumor antigen as described herein.
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公开(公告)号:US20220064316A1
公开(公告)日:2022-03-03
申请号:US17359211
申请日:2021-06-25
发明人: Jennifer Brogdon , Eugene Choi , Hilmar Erhard Ebersbach , David Jonathan Glass , Heather Huet , Carl H. June , Joan Mannick , Michael C. Milone , Leon Murphy , Gabriela Plesa , Celeste Richardson , Marco Ruella , Reshma Singh , Yongqiang Wang , Qilong Wu
IPC分类号: C07K16/28 , C07K14/725 , C07K19/00 , A61P35/00 , C07H21/04 , C07K14/715 , A61K39/395 , A61K38/17 , C12N5/00 , C12N15/63 , C07K14/705 , A61K35/12
摘要: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.
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公开(公告)号:US20210139595A1
公开(公告)日:2021-05-13
申请号:US17083211
申请日:2020-10-28
发明人: Hilmar Erhard Ebersbach , Thomas Huber , Julia Jascur , Celeste Richardson , Reshma Singh , Huijuan Song , Qilong Wu , Jiquan Zhang
IPC分类号: C07K16/28 , A61K39/395 , A61K31/436 , C07K14/725 , C07K14/705 , C07K16/30 , A61K35/28 , A61K31/711 , A61K38/17 , A61K45/06 , C07K14/715 , A61K48/00
摘要: The invention provides compositions and methods for treating diseases associated with expression of CD33. The invention also relates to chimeric antigen receptor (CAR) specific to CD33, vectors encoding the same, and recombinant T cells comprising the CD33 CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD33 binding domain.
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公开(公告)号:US20200377589A1
公开(公告)日:2020-12-03
申请号:US16743772
申请日:2020-01-15
发明人: Gregory Beatty , Boris Engels , Neeraja Idamakanti , Carl H. June , Andreas Loew , Michael C. Milone , Huijuan Song , Enxiu Wang , Qilong Wu
IPC分类号: C07K16/28 , C07K16/30 , C07K14/735 , C07K14/705 , A61K35/17 , C07K14/725 , C07K14/74 , C12N5/0783
摘要: The present invention provides compositions and methods for regulating the specificity and activity of immune effector cells for use in immunotherapy. In one embodiment, the invention provides a type of chimeric antigen receptor (CAR) wherein the CAR is termed a “NKR-CAR” which is a CAR design comprising a component of a receptor naturally found on natural killer (NK) cells. In one embodiment, the NK receptor includes but is not limited to a naturally occurring activating and inhibitory receptor of NK cells known as a killer cell immunoglobulin-like receptor (KIR).
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公开(公告)号:US20190263914A1
公开(公告)日:2019-08-29
申请号:US16210480
申请日:2018-12-05
发明人: Jennifer Brogdon , Boris Engels , David Jonathan Glass , Brian Granda , John Hastewell , Andreas Loew , Joan Mannick , Michael C. Milone , Leon Murphy , William Raj Sellers , Huijuan Song , Brian Edward Vash , Jan Weiler , Qilong Wu , Li Zhou
IPC分类号: C07K16/28 , A61K31/436 , C07K14/725 , C07K14/705 , C07K14/74 , C12N9/90 , A61K35/17 , C07K14/71 , C12N9/12
摘要: Compositions and methods relating to regulatable chimeric antigen receptors (RCARs), where the intracellular signaling or proliferation of the RCAR can be controlled to optimize the use of an RCAR-expressing cell to provide an immune response, are provided. For example, a RCAR can comprise a dimerization switch that, upon the presence of a dimerization molecule, can couple an intracellular signaling domain to an extracellular recognition element, e.g., an antigen binding domain, an inhibitory counter ligand binding domain, or costimulatory ECD domain. An RCAR can be engineered to include an appropriate antigen binding domain that is specific to a desired antigen target and used in the treatment of a disease.
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公开(公告)号:US09777061B2
公开(公告)日:2017-10-03
申请号:US14805236
申请日:2015-07-21
发明人: Hilmar Erhard Ebersbach , Thomas Huber , Julia Jascur , Celeste Richardson , Reshma Singh , Huijuan Song , Qilong Wu , Jiquan Zhang
IPC分类号: C12N5/071 , C12N5/16 , C07K16/28 , C07K14/705 , A61K39/395 , A61K31/436 , C07K14/725 , C07K16/30 , A61K38/17 , A61K45/06 , C07K14/715 , A61K48/00 , A61K35/28 , A61K39/00 , A61K38/00
CPC分类号: C07K16/2851 , A61K31/436 , A61K31/711 , A61K35/28 , A61K38/00 , A61K38/1774 , A61K38/1793 , A61K39/39558 , A61K45/06 , A61K48/00 , A61K2039/505 , A61K2039/5156 , C07K14/7051 , C07K14/70517 , C07K14/7056 , C07K14/70578 , C07K14/7151 , C07K16/2803 , C07K16/30 , C07K16/3061 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/53 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C07K2319/03 , C07K2319/33 , C07K2319/70 , A61K2300/00
摘要: The invention provides compositions and methods for treating diseases associated with expression of CD33. The invention also relates to chimeric antigen receptor (CAR) specific to CD33, vectors encoding the same, and recombinant T cells comprising the CD33 CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD33 binding domain.
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公开(公告)号:US20190153061A1
公开(公告)日:2019-05-23
申请号:US16197565
申请日:2018-11-21
发明人: Jennifer Brogdon , Eugene Choi , Hilmar Erhard Ebersbach , David Jonathan Glass , Heather Huet , Carl H. June , Joan Mannick , Michael C. Milone , Leon Murphy , Gabriela Plesa , Celeste Richardson , Marco Ruella , Reshma Singh , Yongqiang Wang , Qilong Wu
摘要: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.
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公开(公告)号:US10174095B2
公开(公告)日:2019-01-08
申请号:US14805193
申请日:2015-07-21
发明人: Jennifer Brogdon , Eugene Choi , Hilmar Erhard Ebersbach , David Glass , Heather Huet , Carl H. June , Joan Mannick , Michael C. Milone , Leon Murphy , Gabriela Plesa , Celeste Richardson , Marco Ruella , Reshma Singh , Yongqiang Wang , Qilong Wu
IPC分类号: C07H21/04 , C12N15/63 , C12N5/00 , C07K16/28 , C07K14/705 , A61K35/12 , A61K38/17 , C07K14/715 , C07K19/00 , A61K39/395 , A61P35/00
摘要: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.
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