A joint assembly for a guiding device comprises a plurality of guiding elements that are concentrically aligned with respect to one another and at least sectionally spherically shaped. The guiding elements are arranged as components of a combined spherical bearing and comprise spherical contact areas. At least two of the guiding elements are integrally manufactured. The at least two guiding elements enable a relative pivot movement therebetween. A guiding device for an instrument incorporates a respective joint assembly. A method of manufacturing a joint assembly involves integrally manufacturing at least to guiding elements that form components of a combined spherical bearing. Uses of a joint assembly involve a use as a spherical bearing in an instrument holder for a simulation system or an assistance system for minimally invasive operations.