发明授权
- 专利标题： Metabolically robust analogs of CYP-eicosanoids for the treatment of cardiac disease
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申请号： US15746246申请日： 2016-07-22
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公开(公告)号： US11096910B2公开(公告)日： 2021-08-24
- 发明人: Robert Fischer , Anne Konkel , Tim Wesser , Philipp Westphal , Wolf-Hagen Schunk , Christina Westphal , John Russell Falck
- 申请人： OMEICOS THERAPEUTICS GMBH , BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , MAX DELBRUCK-CENTRUM FUR MOLEKULARE MEDIZIN
- 申请人地址： DE Berlin; US TX Austin; DE Berlin
- 专利权人： OMEICOS THERAPEUTICS GMBH,BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM,MAX DELBRUCK-CENTRUM FUR MOLEKULARE MEDIZIN
- 当前专利权人： OMEICOS THERAPEUTICS GMBH,BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM,MAX DELBRUCK-CENTRUM FUR MOLEKULARE MEDIZIN
- 当前专利权人地址： DE Berlin; US TX Austin; DE Berlin
- 代理机构： McDonnell Boehnen Hulbert & Berghoff LLP
- 国际申请： PCT/EP2016/067601 WO 20160722
- 国际公布： WO2017/013265 WO 20170126
- 主分类号： A61P9/00
- IPC分类号： A61P9/00 ; A61K31/08 ; A61K31/202 ; A61K31/18 ; C07C233/56 ; C07C275/20 ; C07C311/17 ; C07D257/04 ; C07C311/51 ; C07D307/60 ; C07D295/192 ; C07D309/14 ; C07D249/12 ; C07D263/48 ; A61K31/557 ; A61P9/10 ; A61P9/06 ; A61P9/04 ; A61K9/00 ; A61K9/12 ; A61K31/17 ; A61K31/4196 ; A61K31/5375
摘要：
The present invention relates to compounds according to general formula (I) which are metabolically robust analogues of bioactive lipid mediators derived from omega-3 polyunsaturated fatty acids (n-3 PUFAs). The present invention further relates to compositions containing one or more of these compounds and to the use of these compounds or compositions for the treatment or prevention of cardiovascular diseases.
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