Invention Grant
- Patent Title: Stabilization of enzyme-immobilized hydrogels for extended hypoxic cell culture
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Application No.: US16212212Application Date: 2018-12-06
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Publication No.: US11124761B2Publication Date: 2021-09-21
- Inventor: Chien-Chi Lin , Camron Scott Dawes , Heiko Konig
- Applicant: Indiana University Research and Technology Corporation
- Applicant Address: US IN Indianapolis
- Assignee: Indiana University Research and Technology Corporation
- Current Assignee: Indiana University Research and Technology Corporation
- Current Assignee Address: US IN Indianapolis
- Agency: Faegre Drinker Biddle & Reath LLP
- Main IPC: C12N5/00
- IPC: C12N5/00 ; G01N33/50 ; C12M1/12 ; C12M1/00
Abstract:
Embodiments of the current invention include a hydrogel formed from crosslinked polyethylene glycol into which acrylated glucose oxidase has been immobilized through crosslinking to the gel. These hydrogels can be used to create hypoxia under ambient conditions for at least 72 hours and can be used to create hypoxic gradients. These embodiments permit the study of cells under a variety of hypoxic conditions.
Public/Granted literature
- US20190177683A1 STABILIZATION OF ENZYME-IMMOBILIZED HYDROGELS FOR EXTENDED HYPOXIC CELL CULTURE Public/Granted day:2019-06-13
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