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公开(公告)号：US11124761B2
公开(公告)日：2021-09-21
申请号：US16212212
申请日：2018-12-06
Inventor： Chien-Chi Lin , Camron Scott Dawes , Heiko Konig
Abstract: Embodiments of the current invention include a hydrogel formed from crosslinked polyethylene glycol into which acrylated glucose oxidase has been immobilized through crosslinking to the gel. These hydrogels can be used to create hypoxia under ambient conditions for at least 72 hours and can be used to create hypoxic gradients. These embodiments permit the study of cells under a variety of hypoxic conditions.
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公开(公告)号：US20190177683A1
公开(公告)日：2019-06-13
申请号：US16212212
申请日：2018-12-06
Inventor： Chien-Chi Lin , Camron Scott Dawes , Heiko Konig
Abstract: Embodiments of the current invention include a hydrogel formed from crosslinked polyethylene glycol into which acrylated glucose oxidase has been immobilized through crosslinking to the gel. These hydrogels can be used to create hypoxia under ambient conditions for at least 72 hours and can be used to create hypoxic gradients. These embodiments permit the study of cells under a variety of hypoxic conditions.
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公开(公告)号：US09364543B2
公开(公告)日：2016-06-14
申请号：US14062296
申请日：2013-10-24
Inventor： Chien-Chi Lin
CPC classification number: A61K47/34 , A61K51/1213 , C08G18/835
Abstract: This disclosure provides compositions comprising a visible light-curable mixture capable of forming a biocompatible hydrogel, hydrogels prepared from the hydrogel precursor mixtures, and a biocompatible delivery system comprising a hydrogel. The disclosure also provides a process for preparing a multi layer hydrogel delivery system.
Abstract translation: 本公开提供了包含能够形成生物相容性水凝胶的可见光固化混合物，由水凝胶前体混合物制备的水凝胶和包含水凝胶的生物相容性递送系统的组合物。 本公开还提供了制备多层水凝胶递送系统的方法。
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