- 专利标题： Bispecific antibodies specific for PD1 and TIM3
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申请号： US16367017申请日： 2019-03-27
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公开(公告)号： US11130810B2公开(公告)日： 2021-09-28
- 发明人: Laura Codarri-Deak , Georg Fertig , Jens Fischer , Christian Klein , Viktor Levitski , Valeria Lifke , Mario Perro , Joerg Thomas Regula , Tilman Schlothauer , Stefan Seeber , Pablo Umana , Ildiko Wuensche , Adrian Zwick
- 申请人： Hoffmann-La Roche Inc.
- 申请人地址： US NJ Little Falls
- 专利权人： Hoffmann-La Roche Inc.
- 当前专利权人： Hoffmann-La Roche Inc.
- 当前专利权人地址： US NJ Little Falls
- 代理机构： Genentech, Inc.
- 优先权： EP15188036 20151002,EP15188065 20151002
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; A61K39/00
摘要：
The invention relates to bispecific antibodies comprising a first antigen-binding site that specifically binds to PD1 and a second antigen-binding site that specifically binds to TIM3, in particular to bispecific antibodies, wherein the bispecific antibody binds to 5 TIM3 with a lower binding affinity when compared to the binding to PD1. The invention further relates to methods of producing these molecules and to methods of using the same.
公开/授权文献
- US20190322748A1 BISPECIFIC ANTIBODIES SPECIFIC FOR PD1 AND TIM3 公开/授权日：2019-10-24
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