公开(公告)号：US20220259327A1

公开(公告)日：2022-08-18

申请号：US17580980

申请日：2022-01-21

Applicant: Hoffmann-La Roche Inc.

Inventor： Maria Amann ,  Peter Bruenker ,  Christina Claus ,  Claudia Ferrara Koller ,  Sandra Grau-Richards ,  Christian Klein ,  Viktor Levitski ,  Ekkehard Moessner ,  Joerg Thomas Regula ,  Pablo Umana

IPC: C07K16/40 ,  C07K16/28 ,  C07K14/705 ,  A61K39/395 ,  C07K16/30

Abstract: The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to a target cell antigen and (b) a first and a second polypeptide that are linked to each other by a disulfide bond, characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand family member or a fragment thereof.

公开(公告)号：US20220259326A1

公开(公告)日：2022-08-18

申请号：US17580970

申请日：2022-01-21

Applicant: Hoffmann-La Roche Inc.

Inventor： Maria Amann ,  Peter Bruenker ,  Christina Claus ,  Claudia Ferrara Koller ,  Sandra Grau-Richards ,  Christian Klein ,  Viktor Levitski ,  Ekkehard Moessner ,  Joerg Thomas Regula ,  Pablo Umana

IPC: C07K16/40 ,  C07K16/28 ,  C07K14/705 ,  A61K39/395 ,  C07K16/30

Abstract: The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to a target cell antigen and (b) a first and a second polypeptide that are linked to each other by a disulfide bond, characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand family member or a fragment thereof.

公开(公告)号：US10392445B2

公开(公告)日：2019-08-27

申请号：US15067024

申请日：2016-03-10

Applicant: Hoffmann-La Roche Inc.

Inventor： Maria Amann ,  Peter Bruenker ,  Christina Claus ,  Claudia Ferrara Koller ,  Sandra Grau-Richards ,  Christian Klein ,  Viktor Levitski ,  Ekkehard Moessner ,  Joerg Thomas Regula ,  Pablo Umana

IPC: C07K16/40 ,  C07K16/28 ,  C07K14/705 ,  A61K39/395 ,  C07K16/30 ,  A61K38/00

Abstract: The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to a target cell antigen and (b) a first and a second polypeptide that are linked to each other by a disulfide bond, characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand family member or a fragment thereof.

公开(公告)号：US20170247454A1

公开(公告)日：2017-08-31

申请号：US15280810

申请日：2016-09-29

Applicant: Hoffmann-La Roche Inc.

Inventor： Joerg Benz ,  Laura Codarri Deak ,  Stefan Dengl ,  Sebastian Fenn ,  Jens Fischer ,  Guy Georges ,  Christian Klein ,  Viktor Levitski ,  Valeria Lifke ,  Oliver Ploettner ,  Stefan Seeber ,  Barbara Weiser ,  Ildiko Wuensche ,  Adrian Zwick

IPC: C07K16/28

CPC classification number: C07K16/2818 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention relates to anti-PD1 antibodies and methods of using the same.

公开(公告)号：US20220267395A1

公开(公告)日：2022-08-25

申请号：US17455617

申请日：2021-11-18

Applicant: Hoffmann-La Roche Inc.

Inventor： Maria Amann ,  Peter Bruenker ,  Christina Claus ,  Claudia Ferrara Koller ,  Sandra Grau-Richards ,  Christian Klein ,  Viktor Levitski ,  Ekkehard Moessner ,  Pablo Umana

IPC: C07K14/525 ,  C07K16/40 ,  C07K16/28 ,  C07K14/705 ,  C07K16/30 ,  A61K39/395

Abstract: The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to a target cell antigen, (b) a polypeptide comprising three ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by peptide linkers and (c) a Fc domain composed of a first and a second subunit capable of stable association, and to methods of producing these molecules and to methods of using the same.

公开(公告)号：US11267903B2

公开(公告)日：2022-03-08

申请号：US16522412

申请日：2019-07-25

Applicant: Hoffmann-La Roche Inc.

Inventor： Maria Amann ,  Peter Bruenker ,  Christina Claus ,  Claudia Ferrara Koller ,  Sandra Grau-Richards ,  Christian Klein ,  Viktor Levitski ,  Ekkehard Moessner ,  Joerg Thomas Regula ,  Pablo Umana

IPC: C07K16/28 ,  C07K14/705 ,  A61K39/395 ,  A61K38/00 ,  C07K16/40 ,  C07K16/30

Abstract: The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to a target cell antigen and (b) a first and a second polypeptide that are linked to each other by a disulfide bond, characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand family member or a fragment thereof.

公开(公告)号：US20190382507A1

公开(公告)日：2019-12-19

申请号：US16522412

申请日：2019-07-25

Applicant: Hoffmann-La Roche Inc.

Inventor： Maria Amann ,  Peter Bruenker ,  Christina Claus ,  Claudia Ferrara Koller ,  Sandra Grau-Richards ,  Christian Klein ,  Viktor Levitski ,  Ekkehard Moessner ,  Joerg Thomas Regula ,  Pablo Umana

IPC: C07K16/40 ,  C07K16/28 ,  C07K14/705 ,  A61K39/395 ,  C07K16/30

Abstract: The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to a target cell antigen and (b) a first and a second polypeptide that are linked to each other by a disulfide bond, characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand family member or a fragment thereof.

公开(公告)号：US20160340399A1

公开(公告)日：2016-11-24

申请号：US15087405

申请日：2016-03-31

Applicant: Hoffmann-La Roche Inc.

Inventor： Maria Amann ,  Peter Bruenker ,  Christina Claus ,  Claudia Ferrara Koller ,  Sandra Grau-Richards ,  Christian Klein ,  Viktor Levitski ,  Ekkehard Moessner ,  Pablo Umana

IPC: C07K14/525

CPC classification number: C07K14/525 ,  A61K38/00 ,  A61K39/395 ,  C07K14/705 ,  C07K14/70596 ,  C07K16/2803 ,  C07K16/2863 ,  C07K16/2887 ,  C07K16/3007 ,  C07K16/3053 ,  C07K16/40 ,  C07K2317/31 ,  C07K2317/526 ,  C07K2317/55 ,  C07K2317/60 ,  C07K2317/622 ,  C07K2319/035 ,  C07K2319/30

Abstract: The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to a target cell antigen, (b) a polypeptide comprising three ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by peptide linkers and (c) a Fc domain composed of a first and a second subunit capable of stable association, and to methods of producing these molecules and to methods of using the same.

Abstract translation: 本发明涉及包含（a）能够与靶细胞抗原特异性结合的至少一个部分的（b）包含TNF配体家族成员或其片段的三个胞外域的多肽的新型含有TNF家族配体三聚体的抗原结合分子， 通过肽接头彼此连接，和（c）由能够稳定结合的第一和第二亚单位组成的Fc结构域，以及产生这些分子的方法及其使用方法。

公开(公告)号：US11149083B2

公开(公告)日：2021-10-19

申请号：US16186443

申请日：2018-11-09

Applicant: Hoffmann—La Roche Inc.

Inventor： Maria Amann ,  Peter Bruenker ,  Christina Claus ,  Claudia Ferrara Koller ,  Sandra Grau-Richards ,  Christian Klein ,  Viktor Levitski ,  Ekkehard Moessner ,  Pablo Umana

IPC: C07K16/18 ,  A61K47/65 ,  A61P35/00 ,  C07K14/525 ,  A61K47/68 ,  C07K14/715 ,  C07K16/24

Abstract: The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one antigen binding moiety capable of specific binding to Tenascin-C (TnC) and (b) a first and a second polypeptide that are linked to each other by a disulfide bond, wherein the antigen binding molecules are characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or two fragments thereof that are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand family member or a fragment thereof. The invention further relates to methods of producing these molecules and to methods of using the same.

公开(公告)号：US11130810B2

公开(公告)日：2021-09-28

申请号：US16367017

申请日：2019-03-27

Applicant: Hoffmann-La Roche Inc.

Inventor： Laura Codarri-Deak ,  Georg Fertig ,  Jens Fischer ,  Christian Klein ,  Viktor Levitski ,  Valeria Lifke ,  Mario Perro ,  Joerg Thomas Regula ,  Tilman Schlothauer ,  Stefan Seeber ,  Pablo Umana ,  Ildiko Wuensche ,  Adrian Zwick

IPC: C07K16/28 ,  A61K39/00

Abstract: The invention relates to bispecific antibodies comprising a first antigen-binding site that specifically binds to PD1 and a second antigen-binding site that specifically binds to TIM3, in particular to bispecific antibodies, wherein the bispecific antibody binds to 5 TIM3 with a lower binding affinity when compared to the binding to PD1. The invention further relates to methods of producing these molecules and to methods of using the same.