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    ANTIBODIES BINDING TO HUMAN AND CYNOMOLGUS CD3 EPSILON
    3.
    发明申请
    ANTIBODIES BINDING TO HUMAN AND CYNOMOLGUS CD3 EPSILON 审中-公开

    公开(公告)号：US20200325224A1

    公开(公告)日：2020-10-15

    申请号：US16751046

    申请日：2020-01-23

    Applicant: Hoffmann-La Roche Inc.

    Inventor： Georg Tiefenthaler ,  Ekkehard Moessner ,  Valeria Lifke ,  Josef Platzer ,  Sonja Offner ,  Christiane Neumann ,  Mirko Ritter

    IPC: C07K16/28

    Abstract: One aspect as reported herein is using a method comprising the step of immunizing an experimental animal, three times with primary cynomolgus PBLs, whereby the PBLs are optionally enriched for T cells without using primary human PBLs as immunogen and without using a denaturing agent for producing a human cynomolgus cross-reactive antibody specifically binding to human CD3 epsilon of SEQ ID NO: 02 and specifically binding to a polypeptide of SEQ ID NO: 01, wherein the human cynomolgus cross-reactive antibody specifically binds to human and cynomolgus T cells, activates human T cells and does not bind to the same epitope as the antibody OKT3, the antibody UCHT1 and/or antibody the SP34.

    ANTIBODIES BINDING TO HUMAN AND CYNOMOLGUS CD3 EPSILON
    4.
    发明申请
    ANTIBODIES BINDING TO HUMAN AND CYNOMOLGUS CD3 EPSILON 审中-公开

    公开(公告)号：US20200299385A1

    公开(公告)日：2020-09-24

    申请号：US16751062

    申请日：2020-01-23

    Applicant: Hoffmann-La Roche Inc.

    Inventor： Georg Tiefenthaler ,  Ekkehard Moessner ,  Valeria Lifke ,  Josef Platzer ,  Sonja Offner ,  Christiane Neumann ,  Mirko Ritter

    IPC: C07K16/28

    Abstract: One aspect as reported herein is using a method comprising the step of immunizing an experimental animal, three times with primary cynomolgus PBLs, whereby the PBLs are optionally enriched for T cells without using primary human PBLs as immunogen and without using a denaturing agent for producing a human cynomolgus cross-reactive antibody specifically binding to human CD3 epsilon of SEQ ID NO: 02 and specifically binding to a polypeptide of SEQ ID NO: 01, wherein the human cynomolgus cross-reactive antibody specifically binds to human and cynomolgus T cells, activates human T cells and does not bind to the same epitope as the antibody OKT3, the antibody UCHT1 and/or antibody the SP34.

    Method for the production of antibodies
    7.
    发明授权
    Method for the production of antibodies 有权
    生产抗体的方法

    公开(公告)号：US08884096B2

    公开(公告)日：2014-11-11

    申请号：US13798280

    申请日：2013-03-13

    Applicant: Hoffmann-La Roche Inc.

    Inventor： Alexander Lifke ,  Valeria Lifke ,  Bernd Mueller-Beckmann ,  Tobias Schnitzer

    IPC: C12P21/00 ,  A61K35/26 ,  A61K35/28 ,  A61K35/54 ,  A61K35/407 ,  A01N63/00 ,  A01N65/00 ,  C12N5/0781 ,  C07K16/00 ,  C07K16/28 ,  C07K16/32

    CPC classification number: C12P21/00 ,  C07K16/00 ,  C07K16/2866 ,  C07K16/32 ,  C12N5/0635

    Abstract: The current invention is related to a method for the production of a human monoclonal antibody from a immunodeficient non-human animal, said method comprising contacting a new borne immunodeficient non-human animal with a human fetal liver stem cell (FL cell) to generate an immune transplanted non-human animal (reconstituted animal), subsequently contacting said reconstituted animal with a antigen, collecting from said reconstituted animal a human cell producing human antibody against said antigen, and isolating said antibody from said antibody producing cell.

    Abstract translation: 本发明涉及从免疫缺陷型非人动物制备人单克隆抗体的方法，所述方法包括使新的免疫缺陷型非人动物与人胎肝干细胞（FL细胞）接触以产生 免疫移植的非人动物（重构动物），随后使所述重建的动物与抗原接触，从所述重建的动物收集产生针对所述抗原的人抗体的人细胞，并从所述抗体产生细胞中分离所述抗体。

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