Invention Grant
- Patent Title: Macrocycles as factor XIA inhibitors
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Application No.: US16691099Application Date: 2019-11-21
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Publication No.: US11136327B2Publication Date: 2021-10-05
- Inventor: James R. Corte , Tianan Fang , Carl P. Decicco , Donald J. P. Pinto , Karen A. Rossi , Zilun Hu , Yoon Jeon , Mimi L. Quan , Joanne M. Smallheer , Yufeng Wang , Wu Yang
- Applicant: Bristol-Myers Squibb Company
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agency: Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D487/08 ; C07D498/08 ; C07D487/06 ; C07D487/16 ; C07D498/06 ; C07D471/18 ; C07D487/18 ; C07D471/14 ; C07D487/14 ; C07D498/04

Abstract:
The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective Factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
Public/Granted literature
- US20200087312A1 MACROCYCLES AS FACTOR XIA INHIBITORS Public/Granted day:2020-03-19
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