A floorplan independent and cross-current free distributed adaptive power multiplexer (APM) is disclosed. In some implementations, an APM includes a first switch path coupled between a first voltage supply rail and an output terminal, the first switch path including a first switch; a second switch path coupled between a second voltage supply rail and the output terminal, the second switch path including a second switch, wherein the first switch and the second switch are configured to select one of a first voltage supply and a second voltage supply as an output voltage supply to be output at the voltage output terminal; and a comparator coupled to the first and the second voltage supply rails, and the voltage output terminal, wherein the comparator is configured to compare the output voltage supply with one of the first and the second voltage supplies and to output a control signal.