A multi-slug staged method for plugging a fractured formation includes: determining an average opening of fractures around a well as D, an average particle size of bridging particles for first-stage plugging as D1 that is slightly less than D, and average particle sizes of plugging particles for second to last-stage plugging as D2-Dn, where Dn is small enough to form a tight plugging layer; and sequentially injecting a plugging slurry only containing the bridging particles having the average particle size of D1, plugging slurries containing the plugging particles having the average particle sizes of D2-Dn-1, and a plugging slurry containing the plugging particles having the average particle size of Dn into the fractures to achieve the fractured formation plugging.