Invention Grant
- Patent Title: Self-assembling protein nanostructures displaying paramyxovirus and/or pneumovirus F proteins and their use
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Application No.: US16500331Application Date: 2018-04-03
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Publication No.: US11192926B2Publication Date: 2021-12-07
- Inventor: Neil P. King , David Baker , Brooke Nickerson , Lance Joseph Stewart , Laurent Perez , Antonio Lanzavecchia , Jessica Marcandalli
- Applicant: UNIVERSITY OF WASHINGTON , INSTITUTE FOR RESEARCH IN BIOMEDICINE
- Applicant Address: US WA Seattle; CH Bellinzona
- Assignee: UNIVERSITY OF WASHINGTON,INSTITUTE FOR RESEARCH IN BIOMEDICINE
- Current Assignee: UNIVERSITY OF WASHINGTON,INSTITUTE FOR RESEARCH IN BIOMEDICINE
- Current Assignee Address: US WA Seattle; CH Bellinzona
- Agency: McDonnell Boehnen Hulbert & Berghoff LLP
- International Application: PCT/US2018/025880 WO 20180403
- International Announcement: WO2018/187325 WO 20181011
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/12 ; A61K39/155 ; C07K14/005 ; A61K39/385 ; A61P31/14 ; B82Y5/00 ; C12N7/00

Abstract:
Disclosed herein are nanostructures and their use, where the nanostructures include (a) a plurality of first assemblies, each first assembly comprising a plurality of identical first polypeptides; (b) a plurality of second assemblies, each second assembly comprising a plurality of identical second polypeptides, wherein the second polypeptide differs from the first polypeptide; wherein the plurality of first assemblies non-covalently interact with the plurality of second assemblies to form a nanostructures; and wherein the nanostructure displays multiple copies of one or more paramyxovirus and/or pneumovirus F proteins or antigenic fragments thereof, on an exterior of the nanostructure.
Information query