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公开(公告)号：US11192926B2
公开(公告)日：2021-12-07
申请号：US16500331
申请日：2018-04-03
发明人： Neil P. King , David Baker , Brooke Nickerson , Lance Joseph Stewart , Laurent Perez , Antonio Lanzavecchia , Jessica Marcandalli
IPC分类号： A61K39/00 , A61K39/12 , A61K39/155 , C07K14/005 , A61K39/385 , A61P31/14 , B82Y5/00 , C12N7/00
摘要： Disclosed herein are nanostructures and their use, where the nanostructures include (a) a plurality of first assemblies, each first assembly comprising a plurality of identical first polypeptides; (b) a plurality of second assemblies, each second assembly comprising a plurality of identical second polypeptides, wherein the second polypeptide differs from the first polypeptide; wherein the plurality of first assemblies non-covalently interact with the plurality of second assemblies to form a nanostructures; and wherein the nanostructure displays multiple copies of one or more paramyxovirus and/or pneumovirus F proteins or antigenic fragments thereof, on an exterior of the nanostructure.
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公开(公告)号：US11732011B2
公开(公告)日：2023-08-22
申请号：US17523174
申请日：2021-11-10
发明人： Neil P. King , David Baker , Brooke Fiala , Lance Joseph Stewart , Laurent Perez , Antonio Lanzavecchia , Jessica Marcandalli
IPC分类号： C12N7/00 , C12N1/15 , C12N15/45 , A61K39/12 , A61K39/155 , C07K14/005 , A61P31/14 , B82Y5/00 , A61K39/00
CPC分类号： C07K14/005 , A61K39/12 , A61P31/14 , B82Y5/00 , C12N7/00 , A61K2039/575 , C07K2319/735 , C12N2760/18022 , C12N2760/18322 , C12N2760/18522
摘要： Disclosed herein are nanostructures and their use, where the nanostructures include (a) a plurality of first assemblies, each first assembly comprising a plurality of identical first polypeptides; (b) a plurality of second assemblies, each second assembly comprising a plurality of identical second polypeptides, wherein the second polypeptide differs from the first polypeptide; wherein the plurality of first assemblies non-covalently interact with the plurality of second assemblies to form a nanostructures; and wherein the nanostructure displays multiple copies of one or more paramyxovirus and/or pneumovirus F proteins or antigenic fragments thereof, on an exterior of the nanostructure.
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公开(公告)号：US10421789B2
公开(公告)日：2019-09-24
申请号：US16291726
申请日：2019-03-04
申请人： University of Washington, Center for Commercialization , The Scripps Research Institute , International AIDS Vaccine Initiative
IPC分类号： A61K39/00 , A61K39/21 , C07K16/10 , A61K39/12 , C07K14/005 , G01N33/564 , A61K38/00
摘要： The invention relates to an engineered outer domain (eOD) of HIV gp120 and mutants thereof and methods of making and using the same. The mutant eODs may be advantageous for the elicitation of CD4-binding site (CD4bs)-directed broadly-neutralizing antibodies (bnAbs) and/or improve binding to mature VRC01 and/or improve binding to germline VRC01 and the germlines of other VH1-2 derived broadly-neutralizing antibodies. The mutant eODs may also include glycan-masking mutations on eOD. The present invention also includes fusions of eOD to various protein multimers to enhance immunogenicity as well as the design of cocktails of different eODs that represent the full diversity of HIV sequences within the VRC01 epitope and surroundings.
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公开(公告)号：US09630994B2
公开(公告)日：2017-04-25
申请号：US14930792
申请日：2015-11-03
发明人： David Baker , Jacob B. Bale , Neil P. King , William H. Sheffler , Daniel Ellis
CPC分类号： C07K14/00
摘要： Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using such synthetic nanostructures are disclosed herein.
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公开(公告)号：US10221217B2
公开(公告)日：2019-03-05
申请号：US14978132
申请日：2015-12-22
申请人： University of Washington, Center For Commercialization , The Scripps Research Institute , International AIDS Vaccine Initiative
IPC分类号： A61K39/00 , A61K39/21 , A61K39/12 , C07K14/005 , C07K16/10 , A61K38/00 , G01N33/564
摘要： The invention relates to an engineered outer domain (eOD) of HIV gp120 and mutants thereof and methods of making and using the same. The mutant eODs may be advantageous for the elicitation of CD4-binding site (CD4bs)-directed broadly-neutralizing antibodies (bnAbs) and/or improve binding to mature VRC01 and/or improve binding to germline VRC01 and the germlines of other VH1-2 derived broadly-neutralizing antibodies. The mutant eODs may also include glycan-masking mutations on eOD. The present invention also includes fusions of eOD to various protein multimers to enhance immunogenicity as well as the design of cocktails of different eODs that represent the full diversity of HIV sequences within the VRC01 epitope and surroundings.
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6.发明申请公开(公告)号：US20160185825A1
公开(公告)日：2016-06-30
申请号：US14978132
申请日：2015-12-22
申请人： University of Washington, Center For Commercialization , The Scripps Research Institute , International AIDS Vaccine Initiative
IPC分类号： C07K14/005
CPC分类号： C07K14/005 , A61K38/00 , A61K39/12 , A61K39/21 , C12N2740/16122 , C12N2740/16134 , G01N33/564
摘要： The invention relates to an engineered outer domain (eOD) of HIV gp120 and mutants thereof and methods of making and using the same. The mutant eODs may be advantageous for the elicitation of CD4-binding site (CD4bs)-directed broadly-neutralizing antibodies (bnAbs) and/or improve binding to mature VRC01 and/or improve binding to germline VRC01 and the germlines of other VH1-2 derived broadly-neutralizing antibodies. The mutant eODs may also include glycan-masking mutations on eOD. The present invention also includes fusions of eOD to various protein multimers to enhance immunogenicity as well as the design of cocktails of different eODs that represent the full diversity of HIV sequences within the VRC01 epitope and surroundings.
摘要翻译： 本发明涉及HIV gp120的工程外结构域（eOD）及其突变体及其制备和使用方法。 突变体eOD可有利于引发CD4结合位点（CD4b） - 定向广泛中和抗体（bnAb）和/或改善与成熟VRC01的结合和/或改善与种系VRC01和其他VH1-2的种系的结合 衍生的广泛中和抗体。 突变体eOD还可以包括eOD上的聚糖掩蔽突变。 本发明还包括将eOD融合到各种蛋白质多聚体以增强免疫原性，以及设计代表VRC01表位和周围环境中HIV序列的完整多样性的不同eOD的鸡尾酒。
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7.发明公开公开(公告)号：US20240277831A1
公开(公告)日：2024-08-22
申请号：US17760174
申请日：2021-02-12
发明人： Neil P. King , David Veesler , Carl Walkey , Alexandra C. Walls , Jing Yang Wang
IPC分类号： A61K39/215 , A61K39/00 , A61P31/14 , C07K14/005
CPC分类号： A61K39/215 , A61P31/14 , C07K14/005 , A61K2039/55555 , A61K2039/575 , C12N2770/20022 , C12N2770/20034
摘要： Disclosed herein are polypeptides comprising an amino acid sequence at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 100% identical to the amino acid sequence selected from the group consisting of SEQ ID NOS:1-84, 138-146, and 167-184, nanoparticles thereof, related nanoparticle compositions, and their use to treat or limit development of an infection.
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公开(公告)号：US11866699B2
公开(公告)日：2024-01-09
申请号：US16476917
申请日：2018-02-12
发明人： Marc Joseph Lajoie , Elizabeth Erin Gray , Neil P. King , Daniel Brewster Stetson , David Baker , Katherine DaPron
IPC分类号： C07H21/04 , C12N15/11 , C07K14/005 , C12N9/22 , C12N15/85
CPC分类号： C12N15/11 , C07K14/005 , C12N9/22 , C12N15/111 , C12N15/85 , C12Y301/21 , C12N2310/20 , C12N2800/80 , C12Q2521/301
摘要： The application discloses multimeric assemblies packaging one or more active component and their use to carry out nucleic acid regulation or gene editing.
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公开(公告)号：US11485759B2
公开(公告)日：2022-11-01
申请号：US16427493
申请日：2019-05-31
发明人： David Baker , Jacob B. Bale , Neil P. King , William H. Sheffler , Daniel Ellis
IPC分类号： C07K14/00
摘要： Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using such synthetic nanostructures are disclosed herein.
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公开(公告)号：US10351603B2
公开(公告)日：2019-07-16
申请号：US15490351
申请日：2017-04-18
发明人： David Baker , Jacob B. Bale , Neil P. King , William H. Sheffler , Daniel Ellis
IPC分类号： C07K14/00
摘要： Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using such synthetic nanostructures are disclosed herein.
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