An in-memory computation device including a memory array, p×q analog to digital converters (ADCs) and a ladder adder is provided. The memory array is divided into p×q memory tiles, where p and q are positive integers larger than 1. Each of the memory tiles has a plurality local bit lines coupled to a global bit line respectively through a plurality of bit line selection switches. The bit line selection switches are turned on or cur off according to a plurality of control signals. The memory array receives a plurality of input signals. The ADCs are respectively coupled to a plurality of global bit lines of the memory tiles. The ADCs respectively convert electrical signals on the global bit lines to generate a plurality of sub-output signals. The ladder adder is coupled to the ADCs, and performs an addition operation on the sub-output signals to generate a calculation result.