Invention Grant
- Patent Title: Increasing ornithine accumulation to increase high mannose glycoform content of recombinant proteins
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Application No.: US16676340Application Date: 2019-11-06
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Publication No.: US11254963B2Publication Date: 2022-02-22
- Inventor: Sohye Kang , Chung Huang, Jr. , Hedieh Barkhordarian , Pavel Bondarenko , Zhongqi Zhang
- Applicant: Amgen Inc.
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: US CA Thousand Oaks
- Agent Henry P. Wu
- Main IPC: C12P21/00
- IPC: C12P21/00 ; C07K16/00 ; C12N1/38 ; C07K14/52 ; C12N5/071
Abstract:
The present invention relates to a method for manipulating the high mannose glycoform content of recombinant glycoproteins by regulating ornithine metabolism during cell culture.
Public/Granted literature
- US20200071738A1 DECREASING ORNITHINE METABOLISM TO DECREASE THE HIGH MANNOSE GLYCOFORM CONTENT OF RECOMBINANT PROTEINS Public/Granted day:2020-03-05
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