Invention Grant
- Patent Title: Methods of conjugating an agent to a thiol moiety in a protein that contains at least one sulfide bond
-
Application No.: US15414330Application Date: 2017-01-24
-
Publication No.: US11370838B2Publication Date: 2022-06-28
- Inventor: Jayme Franklin , Xin Xin Lin , Jeffrey Gorrell , Timothy Tully , Matthew Hutchinson , Charity Tucker Bechtel
- Applicant: GENENTECH, INC.
- Applicant Address: US CA South San Francisco
- Assignee: GENENTECH, INC.
- Current Assignee: GENENTECH, INC.
- Current Assignee Address: US CA South San Francisco
- Agency: Morrison & Foerster LLP
- Main IPC: A61K38/07
- IPC: A61K38/07 ; C07K16/28 ; C07K1/113 ; A61K47/65 ; A61K47/68
Abstract:
The invention provides improved methods of conjugating an agent to a thiol moiety in a protein that contains at least one disulfide bond and at least one trisulfide bond. Exemplary embodiments include the production of antibody drug conjugates substantially free of impurities created in the presence of reactive sulfide moieties in the production processes.
Public/Granted literature
- US20170209593A1 METHODS OF CONJUGATING AN AGENT TO A THIOL MOIETY IN A PROTEIN THAT CONTAINS AT LEAST ONE SULFIDE BOND Public/Granted day:2017-07-27
Information query
IPC分类:
