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公开(公告)号：US11370838B2
公开(公告)日：2022-06-28
申请号：US15414330
申请日：2017-01-24
Applicant: GENENTECH, INC.
Inventor： Jayme Franklin , Xin Xin Lin , Jeffrey Gorrell , Timothy Tully , Matthew Hutchinson , Charity Tucker Bechtel
Abstract: The invention provides improved methods of conjugating an agent to a thiol moiety in a protein that contains at least one disulfide bond and at least one trisulfide bond. Exemplary embodiments include the production of antibody drug conjugates substantially free of impurities created in the presence of reactive sulfide moieties in the production processes.
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